Clinical and ultrasonographic characteristics of pregnancy‐related enhanced myometrial vascularity: prospective cohort study

• Published in: Ultrasound in obstetrics & gynecology Vol. 63; no. 5; pp. 672 - 682
• Main Authors: Xholli, A., Scovazzi, U., Londero, A. P., Paudice, M., Vacca, I., Schiaffino, M. G., Kratochwila, C., Cavalli, E., Perugi, I., Cagnacci, A., Oppedisano, Francesca, Sirito, Giorgio, Ferraro, Mattia F., Molinari, Filippo
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01-05-2024; Wiley Subscription Services, Inc
• Subjects: abnormal uterine bleeding; abortion; Abortion, Induced; Adult; arteriovenous malformation; Blood flow; Blood vessels; Chorionic gonadotropin; Diagnosis; Endometrium; Endometrium - blood supply; Endometrium - diagnostic imaging; enhanced myometrial vascularity; Epidemiology; Female; Gonadotropins; Gynecology; Histology; Humans; Imaging, Three-Dimensional; Management; metrorrhagia; miscarriage; Multiple regression analysis; Myometrium; Myometrium - blood supply; Myometrium - diagnostic imaging; non‐viable pregnancy; Obstetrics; Pituitary (anterior); Pregnancy; pregnancy loss; Pregnancy Trimester, First; Prospective Studies; retained products of conception; Risk factors; termination of pregnancy; Ultrasonic imaging; Ultrasonography, Prenatal; Ultrasound; Velocity; arteriovenous malformation; abortion; enhanced myometrial vascularity; non‐viable pregnancy; pregnancy loss; retained products of conception; miscarriage; metrorrhagia; termination of pregnancy; abnormal uterine bleeding
• ISSN: 0960-7692; 1469-0705
• DOI: 10.1002/uog.27537

ABSTRACT
Objective
To assess the ultrasonographic, epidemiological, clinical and evolutive characteristics of enhanced myometrial vascularity (EMV) following a first‐trimester termination of pregnancy (TOP) or management of non‐viable pregnancy.
Methods
This prospective study included women who underwent follow‐up ultrasound examination 5–6 weeks after a first‐trimester TOP or after management of a first‐trimester non‐viable pregnancy at the University Hospital Polyclinic San Martino of Genoa between March 2021 and March 2022. EMV was characterized using two‐ and three‐dimensional ultrasound and Virtual Organ Computer‐aided Analysis. Ultrasonographic diagnosis of EMV was made when an unusual, tortuous myometrial vessel structure, with high‐velocity blood flow, protruding towards the endometrium was observed, while an abnormal junctional zone, absent endometrial midline and heterogeneous endometrium supported the diagnosis. Patients with EMV underwent expectant management with planned ultrasonographic follow‐up every 2 weeks until resolution.
Results
During the study period, 305 women underwent TOP, of whom 132 attended the initial follow‐up 5–6 weeks later, at which 52 were diagnosed with EMV. Ninety‐six women were managed for a non‐viable pregnancy, of whom 32 presented for follow‐up, at which six had a diagnosis of EMV. Thus, overall, 164 of 401 women were included in the study and EMV was identified in 58 (35%) of these. The prevalence of EMV 5–6 weeks after a TOP was therefore between 52/305 (17%) and 52/132 (39%), and that after management of a non‐viable pregnancy was between 6/96 (6%) and 6/32 (19%). Bleeding/pelvic pain was present in half (29/58) of the women with EMV, and serum human chorionic gonadotropin was detectable in 29% (17/58) at the first follow‐up examination. At ultrasound assessment, all cases with EMV presented abundant tortuous myometrial vessels with high‐velocity flow projecting from the myometrium towards the endometrium, along with non‐uniform heterogeneous endometrium in 97% of cases, which often (67% of these) contained cystic areas, absence of the endometrial midline in 98% of cases and an abnormal junctional zone in 97% of cases (64% interrupted, 33% irregular). Most (67%) women with EMV were parous and 90% of them had undergone TOP rather than management for a non‐viable pregnancy. Medical management of the TOP or non‐viable pregnancy was more frequent in women with than those without EMV (93% vs 77%, P = 0.023). Multiple regression analysis showed the risk of EMV to be increased following TOP vs non‐viable pregnancy (odds ratio (OR), 3.67 (95% CI, 1.16–11.56), P = 0.026) and in parous compared with nulliparous women (OR, 2.95 (95% CI, 1.45–6.01), P = 0.002). All women with EMV underwent expectant management. Eleven women did not return for subsequent follow‐up examinations and did not present to our outpatient or emergency facilities, so were lost to further follow‐up. Spontaneous resolution of the lesion was observed within 7–16 weeks after the procedure in 96% (45/47) of the remaining cases. Two women chose to undergo surgery for pelvic discomfort, and histology showed the presence of neovessels mixed with retained chorionic villi.
Conclusions
EMV is a transient and common finding 5–6 weeks following first‐trimester TOP or management of non‐viable pregnancy. TOP and being parous are risk factors for EMV. Expectant management of EMV is appropriate, because, in almost all cases, this resolves spontaneously, without complications, within 2–4 months. © 2023 International Society of Ultrasound in Obstetrics and Gynecology.