Potential effects of anticoagulants in preclinical mice models of oral cancer: A systematic review

Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. There is mounting evidence to suggest that several components of the coagulation system directly affect carcinogenesis. Our recent in vitro studies demonstrated, for the first time, that various anticoagulants have anticanc...

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Published in:	Oral diseases Vol. 30; no. 3; pp. 962 - 965
Main Authors:	Al‐Azzawi, Huda Moutaz Asmael, Hamza, Syed Ameer, Lin, Zichen, Paolini, Rita, McCullough, Michael, Yap, Tami, Celentano, Antonio
Format:	Journal Article
Language:	English
Published:	Denmark Wiley Subscription Services, Inc 01-04-2024
Subjects:	Animal models Animals Anticoagulants Anticoagulants - pharmacology Anticoagulants - therapeutic use Carcinogenesis Carcinoma, Squamous Cell - drug therapy Disease Models, Animal Head & neck cancer heparin Mice mouth neoplasms Mouth Neoplasms - drug therapy NOACs Oral cancer Oral carcinoma Oral squamous cell carcinoma Pathophysiology Reviews warfarin NOACs heparin anticoagulants mouth neoplasms warfarin
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Abstract	Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. There is mounting evidence to suggest that several components of the coagulation system directly affect carcinogenesis. Our recent in vitro studies demonstrated, for the first time, that various anticoagulants have anticancer effects on OSCC. They also showed the need for the immediate translation of these experimental conditions from bench to preclinical animal models. Here, we carried out a systematic review to summarise existing evidence on murine models built around the interactions between anticoagulants and oral cancer. Only one preclinical murine study was included in our systematic review, investigating the role of heparins in tumour pathophysiology. The paucity of evidence regarding the interactions between oral squamous cell carcinoma and anticoagulants emphasises the urgency with which further preclinical research should be conducted.
AbstractList	Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. There is mounting evidence to suggest that several components of the coagulation system directly affect carcinogenesis. Our recent in vitro studies demonstrated, for the first time, that various anticoagulants have anticancer effects on OSCC. They also showed the need for the immediate translation of these experimental conditions from bench to preclinical animal models. Here, we carried out a systematic review to summarise existing evidence on murine models built around the interactions between anticoagulants and oral cancer. Only one preclinical murine study was included in our systematic review, investigating the role of heparins in tumour pathophysiology. The paucity of evidence regarding the interactions between oral squamous cell carcinoma and anticoagulants emphasises the urgency with which further preclinical research should be conducted.Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. There is mounting evidence to suggest that several components of the coagulation system directly affect carcinogenesis. Our recent in vitro studies demonstrated, for the first time, that various anticoagulants have anticancer effects on OSCC. They also showed the need for the immediate translation of these experimental conditions from bench to preclinical animal models. Here, we carried out a systematic review to summarise existing evidence on murine models built around the interactions between anticoagulants and oral cancer. Only one preclinical murine study was included in our systematic review, investigating the role of heparins in tumour pathophysiology. The paucity of evidence regarding the interactions between oral squamous cell carcinoma and anticoagulants emphasises the urgency with which further preclinical research should be conducted. Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. There is mounting evidence to suggest that several components of the coagulation system directly affect carcinogenesis. Our recent in vitro studies demonstrated, for the first time, that various anticoagulants have anticancer effects on OSCC. They also showed the need for the immediate translation of these experimental conditions from bench to preclinical animal models. Here, we carried out a systematic review to summarise existing evidence on murine models built around the interactions between anticoagulants and oral cancer. Only one preclinical murine study was included in our systematic review, investigating the role of heparins in tumour pathophysiology. The paucity of evidence regarding the interactions between oral squamous cell carcinoma and anticoagulants emphasises the urgency with which further preclinical research should be conducted. Abstract Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. There is mounting evidence to suggest that several components of the coagulation system directly affect carcinogenesis. Our recent in vitro studies demonstrated, for the first time, that various anticoagulants have anticancer effects on OSCC. They also showed the need for the immediate translation of these experimental conditions from bench to preclinical animal models. Here, we carried out a systematic review to summarise existing evidence on murine models built around the interactions between anticoagulants and oral cancer. Only one preclinical murine study was included in our systematic review, investigating the role of heparins in tumour pathophysiology. The paucity of evidence regarding the interactions between oral squamous cell carcinoma and anticoagulants emphasises the urgency with which further preclinical research should be conducted.
Author	Lin, Zichen Yap, Tami Hamza, Syed Ameer Paolini, Rita Celentano, Antonio McCullough, Michael Al‐Azzawi, Huda Moutaz Asmael
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Cites_doi	10.1136/bmj.n71 10.1007/s00228-003-0565-7 10.1111/j.1600-0757.2011.00401.x 10.1016/j.thromres.2019.12.022 10.1111/j.1365-2559.2008.03111.x 10.1016/j.coms.2014.01.001 10.3390/biology11040596 10.1371/journal.pone.0148454 10.3389/fonc.2020.549412 10.1093/ehjcvp/pvw032 10.1111/j.1749-4486.2006.01246.x 10.1186/1758-3284-2-9 10.1158/0008-5472.CAN-14-2887-T 10.1258/la.2011.011087 10.1038/sj.bjc.6603120 10.1016/S0049-3848(10)70017-7 10.3322/caac.20107 10.1038/nrd3185
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Snippet	Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. There is mounting evidence to suggest that several components of the coagulation... Abstract Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. There is mounting evidence to suggest that several components of the...
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SubjectTerms	Animal models Animals Anticoagulants Anticoagulants - pharmacology Anticoagulants - therapeutic use Carcinogenesis Carcinoma, Squamous Cell - drug therapy Disease Models, Animal Head & neck cancer heparin Mice mouth neoplasms Mouth Neoplasms - drug therapy NOACs Oral cancer Oral carcinoma Oral squamous cell carcinoma Pathophysiology Reviews warfarin
Title	Potential effects of anticoagulants in preclinical mice models of oral cancer: A systematic review
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