PRO_SELECT: combining structure-based drug design and combinatorial chemistry for rapid lead discovery. 1. Technology

This paper describes a novel methodology, PRO_SELECT, which combines elements of structure-based drug design and combinatorial chemistry to create a new paradigm for accelerated lead discovery. Starting with a synthetically accessible template positioned in the active site of the target of interest,...

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Bibliographic Details
Published in:	Journal of computer-aided molecular design Vol. 11; no. 2; pp. 193 - 207
Main Authors:	Murray, C W, Clark, D E, Auton, T R, Firth, M A, Li, J, Sykes, R A, Waszkowycz, B, Westhead, D R, Young, S C
Format:	Journal Article
Language:	English
Published:	Netherlands Springer Nature B.V 01-03-1997
Subjects:	Combinatorial analysis Combinatorial chemistry Computer-Aided Design Database searching Databases, Factual Design Drug Design Drugs Evaluation Studies as Topic Inhibitors Lists Models, Chemical Molecular Structure Proteins Scoring Searching Serine Proteinase Inhibitors - chemistry Software Thrombin - antagonists & inhibitors
Online Access:	Get full text
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