Absorption of Drugs Applied to the Gastric Serosal Surface in Rats
The in‐vivo absorption of phenol red, bromphenol blue and bromosulphonphthalein, as model drugs, was investigated after application to the rat gastric serosal surface using a cylindrical glass cell. Absorption ratios of model drugs were estimated to be greater than 37% in 4 h. Absorbed drugs appeare...
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| Published in: | Pharmacy and Pharmacology Communications Vol. 5; no. 8; pp. 519 - 522 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Oxford, UK
Blackwell Publishing Ltd
01-08-1999
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| Online Access: | Get full text |
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| Summary: | The in‐vivo absorption of phenol red, bromphenol blue and bromosulphonphthalein, as model drugs, was investigated after application to the rat gastric serosal surface using a cylindrical glass cell.
Absorption ratios of model drugs were estimated to be greater than 37% in 4 h. Absorbed drugs appeared gradually in plasma and bile. Drug concentrations in the application site at 1 h were 16–660 times that in the non‐application site in the stomach.
Drug application to gastric serosal surface was effective with good absorption and efficient delivery to a local site in the stomach. |
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| Bibliography: | ArticleID:JPHP128 istex:23CACE236CCF9C6D01FA4C4CEAFB0396F533C7AA ark:/67375/WNG-5XRR5XDK-9 |
| ISSN: | 1460-8081 2042-7158 |
| DOI: | 10.1211/146080899128735270 |