Association between a polymorphism in the angiotensin-converting enzyme gene and microvascular complications in Japanese patients with NIDDM

• Published in: Diabetologia Vol. 39; no. 1; pp. 97 - 102
• Main Authors: DOI, Y, YOSHIZUMI, H, YOSHINARI, M, IINO, K, YAMAMOTO, M, ICHIKAWA, K, IWASE, M, FUJISHIMA, M
• Format: Journal Article
• Language: English
• Published: Berlin Springer 1996
• Subjects: Alleles; Associated diseases and complications; Base Sequence; Biological and medical sciences; Diabetes Mellitus, Type 2 - enzymology; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - enzymology; Diabetic Angiopathies - epidemiology; Diabetic Angiopathies - genetics; Diabetic Nephropathies - genetics; Diabetic Nephropathies - therapy; DNA Primers; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Genotype; Humans; Japan; Male; Medical sciences; Middle Aged; Molecular Sequence Data; Peptidyl-Dipeptidase A - genetics; Polymerase Chain Reaction; Polymorphism, Genetic; Proteinuria; Reference Values; Renal Dialysis; Asia; Japan; Endocrinopathy; Human; Urinary system disease; Retinopathy; Enzyme; Renal disease; Non insulin dependent diabetes; Eye disease; Nephropathy; Gene; Peptidyl-dipeptidase A; Hydrolases; Peptidyl-dipeptidases; Complication; Proteinases; Polymorphism
• ISSN: 0012-186X; 1432-0428
• DOI: 10.1007/BF00400419

The relationship between diabetic nephropathy and an insertion (I)/deletion (D) polymorphism in intron 16 of the angiotensin-converting enzyme (ACE) gene is still under debate. The association of ACE gene polymorphism with nephropathy and retinopathy was therefore examined in 362 Japanese patients with non-insulin-dependent diabetes mellitus (NIDDM) and 105 healthy control subjects. Distribution of the ACE genotype did not differ between healthy control subjects and diabetic patients without complications. However, the frequency of the D allele was significantly higher in the diabetic subjects with nephropathy than in those without (0.32 in normoalbuminuric patients vs 0.44 in albuminuria patients with albuminuria) (chi 2 = 7.7; p = 0.006). There was no significant association between ACE genotype and retinopathy. These observations thus demonstrate a significant association of the ACE gene polymorphism with nephropathy, but not with retinopathy, in Japanese patients with NIDDM.