Photophysical Properties of 3-[2-Cyano-4-(dimethylamino)phenyl]alanine: A Highly Fluorescent and Environment-sensitive Amino Acid with Small Molecular Size

Photophysical Properties of 3-[2-Cyano-4-(dimethylamino)phenyl]alanine: A Highly Fluorescent and Environment-sensitive Amino Acid with Small Molecular Size

A new nonnatural amino acid 3-[2-cyano-4-(dimethylamino)phenyl]alanine (CDAPA) is virtually nonfluorescent in water but shows significant enhancement of fluorescence intensity and lifetime when the molecule partitions to nonaqueous environments, suggesting that this molecule is a good candidate as s...

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Bibliographic Details
Published in:Chemistry letters Vol. 35; no. 6; pp. 620 - 621
Main Authors: Oshima, Juro, Tsujimoto, Hitomi, Yoshihara, Toshitada, Yamada, Keiichi, Katakai, Ryoichi, Tobita, Seiji
Format: Journal Article
Language:English
Published: The Chemical Society of Japan 05-06-2006
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Summary:A new nonnatural amino acid 3-[2-cyano-4-(dimethylamino)phenyl]alanine (CDAPA) is virtually nonfluorescent in water but shows significant enhancement of fluorescence intensity and lifetime when the molecule partitions to nonaqueous environments, suggesting that this molecule is a good candidate as small fluorescent probe for proteins.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2006.620