Ribozymomimetic Chemical Synthesis of Peptide Bond Using Phosphorous Acid/Oxirane Mediators

A model system is created that mimics natural ribosome as well as the way of ribozyme action. It uses oxirane analogue as condensation reagent and H 3 PO 3 as activator for the carboxyl group and as protecting reagent for the NH 2 function. In order to demonstrate the ability of the H 3 PO 3 /oxiran...

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Bibliographic Details

Published in:	Phosphorus, sulfur, and silicon and the related elements Vol. 186; no. 2; pp. 338 - 344
Main Authors:	Bayryamov, S., Danalev, D., Vassilev, N.
Format:	Journal Article
Language:	English
Published:	Abingdon Taylor & Francis 01-02-2011 Taylor & Francis Ltd
Subjects:	Carboxyl group Chemical synthesis Cyclic phospholanes Ethylene oxide H-phosphonates oxirane peptide synthesis Peptides Phosphorous acid Reagents ribozymomimetic vicinal hydroxyl group
Online Access:	Get full text
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