Vascular grafts and valves that animate, made from decellularized biologically-engineered tissue tubes

Biologically-engineered matrix - a tissue that is grown in vitro from donor cells, decellularized, and stored prior to use as off-the-shelf allografts - offers a promising alternative to current cardiovascular biomaterials. This perspective reviews preclinical studies and clinical trials of vascular...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of cardiovascular surgery Vol. 61; no. 5; pp. 577 - 585
Main Authors:	Syedain, Zeeshan H, Maciver, Robroy, Tranquillo, Robert T
Format:	Journal Article
Language:	English
Published:	Italy 01-10-2020
Subjects:	Animals Bioprosthesis Blood Vessel Prosthesis Blood Vessel Prosthesis Implantation - adverse effects Blood Vessel Prosthesis Implantation - instrumentation Extracellular Matrix - metabolism Heart Valve Prosthesis Heart Valve Prosthesis Implantation - adverse effects Heart Valve Prosthesis Implantation - instrumentation Humans Prosthesis Design Recovery of Function Tissue Engineering Tissue Scaffolds Vascular Patency
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Biologically-engineered matrix - a tissue that is grown in vitro from donor cells, decellularized, and stored prior to use as off-the-shelf allografts - offers a promising alternative to current cardiovascular biomaterials. This perspective reviews preclinical studies and clinical trials of vascular grafts and valves comprising biologically-engineered matrix, with a focus on those based on donor dermal fibroblast remodeling of fibrin gel with the capacity to heal and grow following recellularization, via animation of the matrix. It concludes with a discussion of related key clinical considerations.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0021-9509 1827-191X
DOI:	10.23736/S0021-9509.20.11615-X