Correlation between peripheral endothelial function, oxygen consumption and ventilatory efficiency in heart transplantation recipients
•Correlation between peripheral endothelial function and VO2peak after HTx.•Correlation between LnRHI and VE/VCO2slope in HTx recipients.•Findings emphasize the importance of the prevention of cardiovascular risk. Endothelial dysfunction and peak oxygen uptake (VO2peak) are also predictors of increa...
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| Published in: | Heart & lung Vol. 64; pp. 208 - 213 |
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| Abstract | •Correlation between peripheral endothelial function and VO2peak after HTx.•Correlation between LnRHI and VE/VCO2slope in HTx recipients.•Findings emphasize the importance of the prevention of cardiovascular risk.
Endothelial dysfunction and peak oxygen uptake (VO2peak) are also predictors of increased risk of cardiovascular events in heart transplantation (HTx) recipients. The preservation of endothelial function may contribute to exercise tolerance.
To investigate the correlation between peripheral endothelial function and exercise tolerance through VO2peak and ventilation to carbon dioxide production slope (VE / VCO2 slope) in HTx recipients.
A pilot cross-sectional study was conducted with adult individuals aged 18-65 years, HTx ≥ six months after surgery, who had a stable medical condition and no changes over the last three months of immunosuppressive treatment. The patients underwent an assessment of endothelial function through PAT (EndoPAT-2000®) and performed a cardiopulmonary exercise test (CPET).
A total of 41% of the studied population presented endothelial dysfunction. The individuals were divided into two groups: the endothelial dysfunction (GED; n=9) group and the normal endothelial function (GNEF; n=13) group according to the logarithm of the reactive hyperemia index (LnRHI). There was a positive and moderate correlation between the LnRHI and VO2 peak (r=0.659, p=0.013) and a negative and moderate correlation between the LnRHI and VE/VCO2 slope (r= -0.686, p= 0.009) in the GNEF. However, no significant correlations were found in the GED.
The results showed that the preservation of peripheral endothelial function is significantly correlated with an increase in exercise tolerance in individuals after HTx. These findings bring important considerations for cardiovascular risk prevention and emphasize that therapeutic strategies with physical training programs must be implemented early. |
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| AbstractList | Endothelial dysfunction and peak oxygen uptake (VO2peak) are also predictors of increased risk of cardiovascular events in heart transplantation (HTx) recipients. The preservation of endothelial function may contribute to exercise tolerance.BACKGROUNDEndothelial dysfunction and peak oxygen uptake (VO2peak) are also predictors of increased risk of cardiovascular events in heart transplantation (HTx) recipients. The preservation of endothelial function may contribute to exercise tolerance.To investigate the correlation between peripheral endothelial function and exercise tolerance through VO2peak and ventilation to carbon dioxide production slope (VE / VCO2 slope) in HTx recipients.OBJECTIVETo investigate the correlation between peripheral endothelial function and exercise tolerance through VO2peak and ventilation to carbon dioxide production slope (VE / VCO2 slope) in HTx recipients.A pilot cross-sectional study was conducted with adult individuals aged 18-65 years, HTx ≥ six months after surgery, who had a stable medical condition and no changes over the last three months of immunosuppressive treatment. The patients underwent an assessment of endothelial function through PAT (EndoPAT-2000®) and performed a cardiopulmonary exercise test (CPET).METHODSA pilot cross-sectional study was conducted with adult individuals aged 18-65 years, HTx ≥ six months after surgery, who had a stable medical condition and no changes over the last three months of immunosuppressive treatment. The patients underwent an assessment of endothelial function through PAT (EndoPAT-2000®) and performed a cardiopulmonary exercise test (CPET).A total of 41% of the studied population presented endothelial dysfunction. The individuals were divided into two groups: the endothelial dysfunction (GED; n=9) group and the normal endothelial function (GNEF; n=13) group according to the logarithm of the reactive hyperemia index (LnRHI). There was a positive and moderate correlation between the LnRHI and VO2 peak (r=0.659, p=0.013) and a negative and moderate correlation between the LnRHI and VE/VCO2 slope (r= -0.686, p= 0.009) in the GNEF. However, no significant correlations were found in the GED.RESULTSA total of 41% of the studied population presented endothelial dysfunction. The individuals were divided into two groups: the endothelial dysfunction (GED; n=9) group and the normal endothelial function (GNEF; n=13) group according to the logarithm of the reactive hyperemia index (LnRHI). There was a positive and moderate correlation between the LnRHI and VO2 peak (r=0.659, p=0.013) and a negative and moderate correlation between the LnRHI and VE/VCO2 slope (r= -0.686, p= 0.009) in the GNEF. However, no significant correlations were found in the GED.The results showed that the preservation of peripheral endothelial function is significantly correlated with an increase in exercise tolerance in individuals after HTx. These findings bring important considerations for cardiovascular risk prevention and emphasize that therapeutic strategies with physical training programs must be implemented early.CONCLUSIONThe results showed that the preservation of peripheral endothelial function is significantly correlated with an increase in exercise tolerance in individuals after HTx. These findings bring important considerations for cardiovascular risk prevention and emphasize that therapeutic strategies with physical training programs must be implemented early. Endothelial dysfunction and peak oxygen uptake (VO ) are also predictors of increased risk of cardiovascular events in heart transplantation (HTx) recipients. The preservation of endothelial function may contribute to exercise tolerance. To investigate the correlation between peripheral endothelial function and exercise tolerance through VO and ventilation to carbon dioxide production slope (VE / VCO ) in HTx recipients. A pilot cross-sectional study was conducted with adult individuals aged 18-65 years, HTx ≥ six months after surgery, who had a stable medical condition and no changes over the last three months of immunosuppressive treatment. The patients underwent an assessment of endothelial function through PAT (EndoPAT-2000®) and performed a cardiopulmonary exercise test (CPET). A total of 41% of the studied population presented endothelial dysfunction. The individuals were divided into two groups: the endothelial dysfunction (GED; n=9) group and the normal endothelial function (GNEF; n=13) group according to the logarithm of the reactive hyperemia index (LnRHI). There was a positive and moderate correlation between the LnRHI and VO (r=0.659, p=0.013) and a negative and moderate correlation between the LnRHI and VE/VCO (r= -0.686, p= 0.009) in the GNEF. However, no significant correlations were found in the GED. The results showed that the preservation of peripheral endothelial function is significantly correlated with an increase in exercise tolerance in individuals after HTx. These findings bring important considerations for cardiovascular risk prevention and emphasize that therapeutic strategies with physical training programs must be implemented early. •Correlation between peripheral endothelial function and VO2peak after HTx.•Correlation between LnRHI and VE/VCO2slope in HTx recipients.•Findings emphasize the importance of the prevention of cardiovascular risk. Endothelial dysfunction and peak oxygen uptake (VO2peak) are also predictors of increased risk of cardiovascular events in heart transplantation (HTx) recipients. The preservation of endothelial function may contribute to exercise tolerance. To investigate the correlation between peripheral endothelial function and exercise tolerance through VO2peak and ventilation to carbon dioxide production slope (VE / VCO2 slope) in HTx recipients. A pilot cross-sectional study was conducted with adult individuals aged 18-65 years, HTx ≥ six months after surgery, who had a stable medical condition and no changes over the last three months of immunosuppressive treatment. The patients underwent an assessment of endothelial function through PAT (EndoPAT-2000®) and performed a cardiopulmonary exercise test (CPET). A total of 41% of the studied population presented endothelial dysfunction. The individuals were divided into two groups: the endothelial dysfunction (GED; n=9) group and the normal endothelial function (GNEF; n=13) group according to the logarithm of the reactive hyperemia index (LnRHI). There was a positive and moderate correlation between the LnRHI and VO2 peak (r=0.659, p=0.013) and a negative and moderate correlation between the LnRHI and VE/VCO2 slope (r= -0.686, p= 0.009) in the GNEF. However, no significant correlations were found in the GED. The results showed that the preservation of peripheral endothelial function is significantly correlated with an increase in exercise tolerance in individuals after HTx. These findings bring important considerations for cardiovascular risk prevention and emphasize that therapeutic strategies with physical training programs must be implemented early. |
| Author | de Moura-Tonello, Sílvia Cristina Garcia de Aguiar, Maria Inês Remígio de Andrade, Armèle Dornelas de Souza, Juliana Andrade Ferreira Barros, Ana Eugênia V.R. Catai, Aparecida Maria Araújo, Bruna T.S. Brandão, Daniella Cunha Campos, Shirley Lima |
| Author_xml | – sequence: 1 givenname: Juliana Andrade Ferreira surname: de Souza fullname: de Souza, Juliana Andrade Ferreira organization: Physiotherapy Department, Federal University of Pernambuco (UFPE), Recife, Brazil – sequence: 2 givenname: Aparecida Maria surname: Catai fullname: Catai, Aparecida Maria organization: Physiotherapy Department, Federal University of Sao Carlos (UFSCAR), São Carlos, Brazil – sequence: 3 givenname: Sílvia Cristina Garcia surname: de Moura-Tonello fullname: de Moura-Tonello, Sílvia Cristina Garcia organization: Physiotherapy Department, Federal University of Sao Carlos (UFSCAR), São Carlos, Brazil – sequence: 4 givenname: Bruna T.S. orcidid: 0000-0001-7754-4397 surname: Araújo fullname: Araújo, Bruna T.S. organization: Physiotherapy Department, Federal University of Pernambuco (UFPE), Recife, Brazil – sequence: 5 givenname: Ana Eugênia V.R. surname: Barros fullname: Barros, Ana Eugênia V.R. organization: Physiotherapy Department, Federal University of Pernambuco (UFPE), Recife, Brazil – sequence: 6 givenname: Maria Inês Remígio surname: de Aguiar fullname: de Aguiar, Maria Inês Remígio organization: Department of Semiology, Hospital das Clínicas, Federal University of Pernambuco, Recife, Brazil – sequence: 7 givenname: Shirley Lima surname: Campos fullname: Campos, Shirley Lima organization: Physiotherapy Department, Federal University of Pernambuco (UFPE), Recife, Brazil – sequence: 8 givenname: Armèle Dornelas surname: de Andrade fullname: de Andrade, Armèle Dornelas organization: Physiotherapy Department, Federal University of Pernambuco (UFPE), Recife, Brazil – sequence: 9 givenname: Daniella Cunha surname: Brandão fullname: Brandão, Daniella Cunha email: daniellacunha@hotmail.com organization: Physiotherapy Department, Federal University of Pernambuco (UFPE), Recife, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38092582$$D View this record in MEDLINE/PubMed |
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| Keywords | endothelial function heart transplant ventilatory efficiency peak oxygen consumption |
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| Snippet | •Correlation between peripheral endothelial function and VO2peak after HTx.•Correlation between LnRHI and VE/VCO2slope in HTx recipients.•Findings emphasize... Endothelial dysfunction and peak oxygen uptake (VO ) are also predictors of increased risk of cardiovascular events in heart transplantation (HTx) recipients.... Endothelial dysfunction and peak oxygen uptake (VO2peak) are also predictors of increased risk of cardiovascular events in heart transplantation (HTx)... |
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| Title | Correlation between peripheral endothelial function, oxygen consumption and ventilatory efficiency in heart transplantation recipients |
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