The effect of a diet rich in Brussels sprouts on warfarin pharmacokinetics

Ten healthy subjects were given 20 mg of warfarin orally before, and after a daily intake of 400 g of brussels sprouts for 2 weeks. The brussels sprouts diet stimulated warfarin disposal as evidenced by a 29% increase in mean elimination rate constant, accompanied by a 27% increase in metabolic clea...

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Bibliographic Details
Published in:	European journal of clinical pharmacology Vol. 34; no. 5; pp. 521 - 523
Main Authors:	OVESEN, L, LYDUCH, S, IDORN, M. L
Format:	Journal Article
Language:	English
Published:	Heidelberg Springer 01-01-1988 Berlin
Subjects:	Adult Biological and medical sciences Blood Coagulation - drug effects Blood. Blood coagulation. Reticuloendothelial system Diet Female Humans Male Medical sciences Pharmacology. Drug treatments Vegetables Warfarin - pharmacokinetics Warfarin - pharmacology Human Brussels sprout Oral administration Anticoagulant Normal Pharmacokinetics Food drug interaction
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Summary:	Ten healthy subjects were given 20 mg of warfarin orally before, and after a daily intake of 400 g of brussels sprouts for 2 weeks. The brussels sprouts diet stimulated warfarin disposal as evidenced by a 29% increase in mean elimination rate constant, accompanied by a 27% increase in metabolic clearance rate and a 16% decrease in plasma AUC. It is concluded that a high intake of brussels sprouts, a cruciferous vegetable, accelerates warfarin disposal, and thereby might contribute to less anticoagulation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0031-6970 1432-1041
DOI:	10.1007/BF01046714