Use of bi-allelic insertion/deletion polymorphisms as a positive control for fetal genotyping in maternal blood: first clinical experience

Amplification of fetal DNA in maternal plasma is a new way for non-invasive fetal genotyping in pregnancies at risk for disorders where the presence of a paternal DNA sequence contributes to the risk status of the fetus. We describe the use of a panel of 10 bi-allelic highly polymorphic markers to a...

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Bibliographic Details
Published in:	Annals of the New York Academy of Sciences Vol. 1075; no. 1; pp. 123 - 129
Main Authors:	Page-Christiaens, Godelieve C M L, Bossers, Bernadette, VAN DER Schoot, C Ellen, DE Haas, Masja
Format:	Journal Article
Language:	English
Published:	United States 01-09-2006
Subjects:	Alleles DNA - blood Female Fetus - physiology Gene Deletion Genetic Markers Genotype Humans Male Maternal-Fetal Exchange Polymorphism, Genetic Pregnancy Prenatal Diagnosis Rh-Hr Blood-Group System - genetics
Online Access:	Get full text
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Summary:	Amplification of fetal DNA in maternal plasma is a new way for non-invasive fetal genotyping in pregnancies at risk for disorders where the presence of a paternal DNA sequence contributes to the risk status of the fetus. We describe the use of a panel of 10 bi-allelic highly polymorphic markers to ascertain the presence and amplification of fetal DNA in case the fetus is negative for the targeted paternal "disease" sequence.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0077-8923 1749-6632
DOI:	10.1196/annals.1368.016