Radical Prostatectomy or Watchful Waiting in Early Prostate Cancer

In this randomized trial, conducted between 1989 and 2022 to compare radical prostatectomy with watchful waiting, radical prostatectomy led to a 48% lower risk of death from prostate cancer and to 2.2 life-years gained.

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Published in:	The New England journal of medicine Vol. 391; no. 14; pp. 1362 - 1364
Main Authors:	Holmberg, Lars, Garmo, Hans, Andersson, Swen-Olof, Andrén, Ove, Johansson, Eva, Taari, Kimmo, Häggman, Michael, Nordling, Stig, Busch, Christer, Adami, Hans-Olov, Johansson, Jan-Erik, Bill-Axelson, Anna
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 10-10-2024
Subjects:	Genitourinary Cancer Hematology Humans Life expectancy Male Medicin och hälsovetenskap Oncology Patients Prostate cancer Prostate Disease Prostate Disease General Prostate-Specific Antigen - blood Prostatectomy Prostatic Neoplasms - surgery Treatments in Oncology Urology Watchful Waiting
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Abstract	In this randomized trial, conducted between 1989 and 2022 to compare radical prostatectomy with watchful waiting, radical prostatectomy led to a 48% lower risk of death from prostate cancer and to 2.2 life-years gained.
AbstractList	30-Year Results of the SPCG-4 Prostate Cancer TrialIn this randomized trial, conducted between 1989 and 2022 to compare radical prostatectomy with watchful waiting, radical prostatectomy led to a 48% lower risk of death from prostate cancer and to 2.2 life-years gained. In this randomized trial, conducted between 1989 and 2022 to compare radical prostatectomy with watchful waiting, radical prostatectomy led to a 48% lower risk of death from prostate cancer and to 2.2 life-years gained.
Author	Andersson, Swen-Olof Häggman, Michael Adami, Hans-Olov Johansson, Jan-Erik Busch, Christer Andrén, Ove Garmo, Hans Bill-Axelson, Anna Taari, Kimmo Nordling, Stig Holmberg, Lars Johansson, Eva
Author_xml	– sequence: 1 givenname: Lars surname: Holmberg fullname: Holmberg, Lars email: lars.holmberg@kcl.ac.uk organization: Uppsala University, Uppsala, Sweden – sequence: 2 givenname: Hans surname: Garmo fullname: Garmo, Hans email: lars.holmberg@kcl.ac.uk organization: Uppsala University, Uppsala, Sweden – sequence: 3 givenname: Swen-Olof surname: Andersson fullname: Andersson, Swen-Olof organization: Örebro University, Örebro, Sweden – sequence: 4 givenname: Ove surname: Andrén fullname: Andrén, Ove organization: Örebro University, Örebro, Sweden – sequence: 5 givenname: Eva surname: Johansson fullname: Johansson, Eva organization: Uppsala University, Uppsala, Sweden – sequence: 6 givenname: Kimmo surname: Taari fullname: Taari, Kimmo organization: Helsinki University Hospital, Helsinki, Finland – sequence: 7 givenname: Michael surname: Häggman fullname: Häggman, Michael organization: Uppsala University, Uppsala, Sweden – sequence: 8 givenname: Stig surname: Nordling fullname: Nordling, Stig organization: University of Helsinki, Helsinki, Finland – sequence: 9 givenname: Christer surname: Busch fullname: Busch, Christer organization: Uppsala University, Uppsala, Sweden – sequence: 10 givenname: Hans-Olov surname: Adami fullname: Adami, Hans-Olov organization: Karolinska Institutet, Stockholm, Sweden – sequence: 11 givenname: Jan-Erik surname: Johansson fullname: Johansson, Jan-Erik organization: University of Helsinki, Helsinki, Finland – sequence: 12 givenname: Anna surname: Bill-Axelson fullname: Bill-Axelson, Anna organization: Uppsala University, Uppsala, Sweden
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Cites_doi	10.1001/jama.1993.03500200064035 10.1056/NEJMoa1807801 10.1097/JU.0000000000004039 10.1056/NEJMoa2214122 10.1016/j.eururo.2020.02.009
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References	Bill-Axelson, A, Holmberg, L, Garmo, H (r1) 2018; 379 Hamdy, FC, Donovan, JL, Lane, JA (r3) 2023; 388 Vickers, A, Vertosick, E, Langsetmo, L, Dahm, P, Steineck, G, Wilt, TJ (r4) 2024; 212 Wilt, TJ, Vo, TN, Langsetmo, L (r2) 2020; 77 Fleming, C, Wasson, JH, Albertsen, PC, Barry, MJ, Wennberg, JE (r5) 1993; 269 e_1_3_3_6_2 e_1_3_3_5_2 e_1_3_3_2_2 e_1_3_3_4_2 e_1_3_3_3_2
References_xml	– volume: 269 start-page: 2650 year: 1993 end-page: 2658 ident: r5 article-title: A decision analysis of alternative treatment strategies for clinically localized prostate cancer. publication-title: JAMA contributor: fullname: Wennberg, JE – volume: 379 start-page: 2319 year: 2018 end-page: 2329 ident: r1 article-title: Radical prostatectomy or watchful waiting in prostate cancer — 29-year follow-up. publication-title: N Engl J Med contributor: fullname: Garmo, H – volume: 212 start-page: 310 year: 2024 end-page: 319 ident: r4 article-title: Estimating the effect of radical prostatectomy: combining data from the SPCG4 and PIVOT randomized trials with contemporary cohorts. publication-title: J Urol contributor: fullname: Wilt, TJ – volume: 77 start-page: 713 year: 2020 end-page: 724 ident: r2 article-title: Radical prostatectomy or observation for clinically localized prostate cancer: extended follow-up of the prostate cancer intervention versus observation trial (PIVOT). publication-title: Eur Urol contributor: fullname: Langsetmo, L – volume: 388 start-page: 1547 year: 2023 end-page: 1558 ident: r3 article-title: Fifteen-year outcomes after monitoring, surgery, or radiotherapy for prostate cancer. publication-title: N Engl J Med contributor: fullname: Lane, JA – ident: e_1_3_3_6_2 doi: 10.1001/jama.1993.03500200064035 – ident: e_1_3_3_2_2 doi: 10.1056/NEJMoa1807801 – ident: e_1_3_3_5_2 doi: 10.1097/JU.0000000000004039 – ident: e_1_3_3_4_2 doi: 10.1056/NEJMoa2214122 – ident: e_1_3_3_3_2 doi: 10.1016/j.eururo.2020.02.009
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Snippet	In this randomized trial, conducted between 1989 and 2022 to compare radical prostatectomy with watchful waiting, radical prostatectomy led to a 48% lower risk... 30-Year Results of the SPCG-4 Prostate Cancer TrialIn this randomized trial, conducted between 1989 and 2022 to compare radical prostatectomy with watchful...
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SubjectTerms	Genitourinary Cancer Hematology Humans Life expectancy Male Medicin och hälsovetenskap Oncology Patients Prostate cancer Prostate Disease Prostate Disease General Prostate-Specific Antigen - blood Prostatectomy Prostatic Neoplasms - surgery Treatments in Oncology Urology Watchful Waiting
SubjectTermsDisplay	Genitourinary Cancer Hematology/Oncology Treatments in Oncology Urology/Prostate Disease Urology/Prostate Disease General
Title	Radical Prostatectomy or Watchful Waiting in Early Prostate Cancer
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