Adaptation of a strain of Plasmodium falciparum from Ghana to Aotus lemurinus griseimembra, A. nancymai, and A. vociferans monkeys

A strain of Plasmodium falciparum from Ghana was adapted to Aotus lemurinus griseimembra, A. nancymai, and A. vociferans monkeys. Gametocytes in splenectomized A. nancymai were infective to Anopheles freeborni mosquitoes. Sporozoite transmission was accomplished in two splenectomized A. nancymai wit...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene Vol. 69; no. 6; p. 593
Main Authors: Sullivan, Joann S, Sullivan, James J, Williams, Allison, Grady, Katharine K, Bounngaseng, Amy, Huber, Curtis S, Nace, Douglas, Williams, Tyrone, Galland, G Gale, Barnwell, John W, Collins, William E
Format: Journal Article
Language:English
Published: United States 01-12-2003
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Summary:A strain of Plasmodium falciparum from Ghana was adapted to Aotus lemurinus griseimembra, A. nancymai, and A. vociferans monkeys. Gametocytes in splenectomized A. nancymai were infective to Anopheles freeborni mosquitoes. Sporozoite transmission was accomplished in two splenectomized A. nancymai with prepatent periods of 22 and 25 days. The Ghana III/CDC strain of P. falciparum is susceptible to treatment with chloroquine and mefloquine.
ISSN:0002-9637
DOI:10.4269/ajtmh.2003.69.593