Engineering Interfacial Integrity with Hydrolytic-Resistant, Self-Reinforcing Dentin Adhesive

• Published in: International journal of molecular sciences Vol. 25; no. 13; p. 7061
• Main Authors: Demirel, Erhan, Korkmaz, Burak, Chang, Youngwoo, Misra, Anil, Tamerler, Candan, Spencer, Paulette
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27-06-2024
• Subjects: Adhesives; Bacteria; Bisphenol A-Glycidyl Methacrylate - chemistry; Bond strength; Collagen; Composite materials; Dental Cements - chemistry; Dentin; Dentin - chemistry; Dentin-Bonding Agents - chemistry; dynamic mechanical analysis; Humans; Hydrolysis; interface study; Investigations; Materials Testing; Mechanical properties; Methacrylates - chemistry; Physical properties; Polymerization; Raman spectroscopy; short-chain monomer; silane monomer; Silanes - chemistry; sol-gel reaction; Spectrum Analysis, Raman; Temperature; Water; dental adhesive; sol-gel reaction; short-chain monomer; silane monomer; interface study; Raman spectroscopy; dynamic mechanical analysis
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25137061

The leading cause of composite restoration failure is secondary caries, and although caries is a multifactorial problem, weak, damage-prone adhesives play a pivotal role in the high susceptibility of composite restorations to secondary caries. Our group has developed synthetic resins that capitalize on free-radical polymerization and sol-gel reactions to provide dental adhesives with enhanced properties. The resins contain γ-methacryloxypropyltrimethoxysilane (MPS) as the Si-based compound. This study investigated the properties of methacrylate-based resins containing methacryloxymethyltrimethoxysilane (MMeS) as a short-chain alternative. The degree of conversion (DC), polymerization kinetics, water sorption, mechanical properties, and leachates of MMeS- and MPS-resins with 55 and 30 wt% BisGMA-crosslinker were determined. The formulations were used as model adhesives, and the adhesive/dentin (a/d) interfaces were analyzed using chemometrics-assisted micro-Raman spectroscopy. The properties of the 55 wt% formulations were comparable. In the 30 wt% BisGMA formulations, the MMeS-resin exhibited faster polymerization, lower DC, reduced leachates, and increased storage and loss moduli, glass transition (T
), crosslink density, and heterogeneity. The spectroscopic results indicated a comparable spatial distribution of resin, mineralized, and demineralized dentin across the a/d interfaces. The hydrolytically stable experimental short-chain-silane-monomer dental adhesive provides enhanced mechanical properties through autonomous strengthening and offers a promising strategy for the development of restorative dental materials with extended service life.