TCRγδ+ large granular lymphocyte leukemias reflect the spectrum of normal antigen-selected TCRγδ+ T-cells

T-cell large granular lymphocytes (LGL) proliferations range from reactive expansions of activated T cells to T-cell leukemias and show variable clinical presentation and disease course. The vast majority of T-LGL proliferations express TCRαβ. Much less is known about the characteristics and pathoge...

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Bibliographic Details
Published in:	Leukemia Vol. 20; no. 3; pp. 505 - 513
Main Authors:	SANDBERG, Y, ALMEIDA, J, SAN MIGUEL, J. F, ORFAO, A, LANGERAK, A. W, GONZALEZ, M, LIMA, M, BARCENA, P, SZCZEPANSKI, T, VAN GASTEL-MOL, E. J, WIND, H, BALANZATEGUI, A, VAN DONGEN, J. J. M
Format:	Journal Article
Language:	English
Published:	London Nature Publishing 01-03-2006 Nature Publishing Group
Subjects:	Anemia Antigens Biological and medical sciences CD11b antigen CD11c antigen CD16 antigen CD5 antigen CD56 antigen CD57 antigen CD7 antigen CD8 antigen Gene rearrangement Hematologic and hematopoietic diseases Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes Lymphocytes T Medical sciences Neutropenia Pancytopenia Pathogenesis Patients Splenomegaly T cell receptors Thrombocytopenia Thymus Human TCRG Immunophenotype γ/δ T cell receptor Selection TCRD Malignant hemopathy antigen-selection Antigen LGL Chronic T-LGL leukemia Lymphoproliferative syndrome T-Lymphocyte Large Granular Lymphocyte Leukemia Vγ/Vδ usage
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