Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashion

Recent studies in our laboratory have shown that UCN-01 (7-hydroxystaurosporine), which is a derivative of the non-selective protein kinase inhibitor staurosporine that exhibits relative selectivity for protein kinase C (PKC), is a potent inhibitor of glioma growth in in vitro and in vivo models. Th...

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Bibliographic Details
Published in:	Journal of neuro-oncology Vol. 41; no. 1; pp. 9 - 20
Main Authors:	BREDEL, M, POLLACK, I. F, FREUND, J. M, RUSNAK, J, LAZO, J. S
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer 1999 Springer Nature B.V
Subjects:	Alkaloids - pharmacology Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis Biological and medical sciences Brain Neoplasms - enzymology Brain Neoplasms - pathology Chemotherapy Coloring Agents Electrophoresis, Agar Gel Enzyme Inhibitors - pharmacology Glioma - enzymology Glioma - pathology Humans In Situ Nick-End Labeling Medical sciences Pharmacology. Drug treatments Protein Kinase C - antagonists & inhibitors Staurosporine - analogs & derivatives Time Factors Trypan Blue Tumor Cells, Cultured Antineoplastic agent Human Cell culture Nervous system diseases Protein kinase C Enzyme Transferases Glioblastoma Enzyme inhibitor Malignant tumor Malignant glioma Chemotherapy Treatment Central nervous system disease Apoptosis
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