Optical Biomedical Diagnostics Using Lab-on-Fiber Technology: A Review

Optical Biomedical Diagnostics Using Lab-on-Fiber Technology: A Review

Point-of-care and in-vivo bio-diagnostic tools are the current need for the present critical scenarios in the healthcare industry. The past few decades have seen a surge in research activities related to solving the challenges associated with precise on-site bio-sensing. Cutting-edge fiber optic tec...

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Published in:Photonics Vol. 9; no. 2; p. 86
Main Authors: Gupta, Banshi D., Pathak, Anisha, Shrivastav, Anand M.
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-02-2022
Subjects:
Biosensors
Chemical vapor deposition
Design
fiber optic sensors
Fiber optics
Fiber technology
fluorescence
interferometry
Ion beams
Light
Morphology
Nanomaterials
Nanostructured materials
Nanotechnology
Optical fibers
Response time
Selectivity
Sensors
SERS
Spectrum analysis
SPR
synthesis
Target detection
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Abstract Point-of-care and in-vivo bio-diagnostic tools are the current need for the present critical scenarios in the healthcare industry. The past few decades have seen a surge in research activities related to solving the challenges associated with precise on-site bio-sensing. Cutting-edge fiber optic technology enables the interaction of light with functionalized fiber surfaces at remote locations to develop a novel, miniaturized and cost-effective lab on fiber technology for bio-sensing applications. The recent remarkable developments in the field of nanotechnology provide innumerable functionalization methodologies to develop selective bio-recognition elements for label free biosensors. These exceptional methods may be easily integrated with fiber surfaces to provide highly selective light-matter interaction depending on various transduction mechanisms. In the present review, an overview of optical fiber-based biosensors has been provided with focus on physical principles used, along with the functionalization protocols for the detection of various biological analytes to diagnose the disease. The design and performance of these biosensors in terms of operating range, selectivity, response time and limit of detection have been discussed. In the concluding remarks, the challenges associated with these biosensors and the improvement required to develop handheld devices to enable direct target detection have been highlighted.
AbstractList Point-of-care and in-vivo bio-diagnostic tools are the current need for the present critical scenarios in the healthcare industry. The past few decades have seen a surge in research activities related to solving the challenges associated with precise on-site bio-sensing. Cutting-edge fiber optic technology enables the interaction of light with functionalized fiber surfaces at remote locations to develop a novel, miniaturized and cost-effective lab on fiber technology for bio-sensing applications. The recent remarkable developments in the field of nanotechnology provide innumerable functionalization methodologies to develop selective bio-recognition elements for label free biosensors. These exceptional methods may be easily integrated with fiber surfaces to provide highly selective light-matter interaction depending on various transduction mechanisms. In the present review, an overview of optical fiber-based biosensors has been provided with focus on physical principles used, along with the functionalization protocols for the detection of various biological analytes to diagnose the disease. The design and performance of these biosensors in terms of operating range, selectivity, response time and limit of detection have been discussed. In the concluding remarks, the challenges associated with these biosensors and the improvement required to develop handheld devices to enable direct target detection have been highlighted.
Author Gupta, Banshi D.
Pathak, Anisha
Shrivastav, Anand M.
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  fullname: Pathak, Anisha
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  givenname: Anand M.
  orcidid: 0000-0002-3257-2818
  surname: Shrivastav
  fullname: Shrivastav, Anand M.
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Snippet Point-of-care and in-vivo bio-diagnostic tools are the current need for the present critical scenarios in the healthcare industry. The past few decades have...
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SubjectTerms Biosensors
Chemical vapor deposition
Design
fiber optic sensors
Fiber optics
Fiber technology
fluorescence
interferometry
Ion beams
Light
Morphology
Nanomaterials
Nanostructured materials
Nanotechnology
Optical fibers
Response time
Selectivity
Sensors
SERS
Spectrum analysis
SPR
synthesis
Target detection
Title Optical Biomedical Diagnostics Using Lab-on-Fiber Technology: A Review
URI https://www.proquest.com/docview/2633046926
https://doaj.org/article/d97c94583c9240d39b2cee6096b99f71
Volume 9
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