Longitudinal changes in renal volumes evaluated by automated three-dimensional volumetric computed tomography of the whole kidney: The association with the renal function and disease progression

• Published in: European journal of radiology Vol. 170; p. 111245
• Main Authors: Narikiyo, Koji, Tanabe, Masahiro, Higashi, Mayumi, Kawano, Yosuke, Inoue, Atsuo, Kiyoyama, Haruka, Kamamura, Naohiko, Kobayashi, Taiga, Ueda, Takaaki, Ito, Katsuyoshi
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01-01-2024
• Subjects: Chronic; Imaging; Kidney; Multidetector computed tomography; Renal insufficiency; Three-dimensional; Renal insufficiency; Chronic; Three-dimensional; Imaging; Kidney; Multidetector computed tomography
• ISSN: 0720-048X; 1872-7727
• DOI: 10.1016/j.ejrad.2023.111245

•The total renal volumes showed positively correlation with the eGFR and CKD grade.•Renal volumes at the initial CT examination were smaller in the progression group.•The renal volumetry is helpful to predict increased risk of CKD grade progression.
To clarify the changes in the total renal volume over time with changes of the renal function using automated 3D volumetric CT of the whole kidney and to evaluate the usefulness of the total renal volume CT measurement in predicting chronic kidney disease (CKD) grade progression.
A total of 961 patients who underwent abdominal CT at least twice (an interval of more than 4 years) were included. The automated 3D volumetric CT measurement of the whole kidney was performed at the initial and latest CT examination. Patients with CKD grade G2 at the time of the initial CT were divided into two groups: a progression group (CKD grade progressed to G3-G5) and a non-progression group. Changes in the renal volume over time were compared between the two groups.
The volume of both kidneys measured on initial CT was positively correlated with eGFR (ρ = 0.490, p < 0.001). There was a significant difference in the initial volume of both kidneys among CKD grades (p < 0.001, G1:318.7 ± 60.5 ml, G2:275.5 ± 53.5 ml, G3:233.7 ± 46.9 ml, G4:183.2 ± 22.5 ml, G5:157.7 ± 77.4 ml). When comparing the progression and non-progression groups, the initial volume of both kidneys was significantly smaller in the progression group, compared with the non-progression group (252.0 ± 50.6 ml vs. 278.9 ± 53.7 ml). In addition, the annual reduction volume in both the right and left kidneys was significantly greater in the progression group than in the non-progression group (p < 0.001).
The automated 3D volumetric CT measurement of the whole kidney has the potential to monitor changes in renal volume over time with changes of the renal function.