Cationic Proteins Inhibit L-Arginine Uptake in Rat Alveolar Macrophages and Tracheal Epithelial Cells . Implications for Nitric Oxide Synthesis

Eosinophil-derived cationic proteins play an essential role in the pathogenesis of bronchial asthma. We tested whether cationic proteins interfere with the cationic amino-acid transport in alveolar macrophages (AMPhi) and tracheal epithelial cells, and whether L-arginine-dependent pathways were affe...

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Bibliographic Details
Published in:	American journal of respiratory cell and molecular biology Vol. 21; no. 2; pp. 155 - 162
Main Authors:	Hammermann, Rainer, Hirschmann, Joachim, Hey, Claudia, Mossner, Jutta, Folkerts, Gert, Nijkamp, Frans P, Wessler, Ignaz, Racke, Kurt
Format:	Journal Article
Language:	English
Published:	United States Am Thoracic Soc 01-08-1999 American Thoracic Society
Subjects:	Animals Arginase - pharmacology Arginine - pharmacokinetics Blood Proteins - pharmacology Citrulline - pharmacology Dose-Response Relationship, Drug Eosinophil Granule Proteins Epithelial Cells - metabolism Female Fibrinolytic Agents - pharmacology Gene Expression Heparin - pharmacology Lipopolysaccharides - pharmacology Lung - metabolism Lysine - metabolism Macrophages, Alveolar - metabolism Male Nitric Oxide - biosynthesis Nitrites - metabolism Rats Rats, Sprague-Dawley Ribonucleases Time Factors Trachea - metabolism
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