The squalestatins: Synthesis of c-4 carboxamide derivatives

The squalestatins: Synthesis of c-4 carboxamide derivatives

Synthesis of squalcstalin S1 C-4 carboxamide, 2, as well as related C-4 amides and C-4 hydroxymethyl derivatives possessing a C-3 hydroxymethyl group (15 and 19) together with their SQS inhibitory activities arc presented.

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Bibliographic Details
Published in:Tetrahedron letters Vol. 37; no. 49; pp. 8925 - 8928
Main Authors: Chan, Chuen, Scicinski, Jan J, Srikantha, Anton Rp, Watson, Nigel S
Format: Journal Article
Language:English
Published: Elsevier Ltd 02-12-1996
Online Access:Get full text
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Description
Summary:Synthesis of squalcstalin S1 C-4 carboxamide, 2, as well as related C-4 amides and C-4 hydroxymethyl derivatives possessing a C-3 hydroxymethyl group (15 and 19) together with their SQS inhibitory activities arc presented.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(96)02049-7