Self-regressing S100-negative CD1a-positive cutaneous histiocytosis

In the skin, the antigen-presenting cells are mainly represented by Langerhans cells, indeterminate cells, and interstitial dendritic cells, which show distinctive immunophenotype and/or ultrastructure. We report a case of a cutaneous-limited self-regressing histiocytosis with a peculiar immunohisto...

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Bibliographic Details
Published in:	The American journal of dermatopathology Vol. 35; no. 4; pp. e57 - e59
Main Authors:	Tardío, Juan C, Aguado, Marta, Borbujo, Jesús
Format:	Journal Article
Language:	English
Published:	United States 01-06-2013
Subjects:	Antigens, CD1 - analysis Biomarkers - analysis Biopsy Cell Proliferation Female Histiocytosis - immunology Histiocytosis - pathology Humans Immunohistochemistry Immunophenotyping Middle Aged Remission, Spontaneous S100 Proteins - analysis Skin Diseases - immunology Skin Diseases - pathology
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Summary:	In the skin, the antigen-presenting cells are mainly represented by Langerhans cells, indeterminate cells, and interstitial dendritic cells, which show distinctive immunophenotype and/or ultrastructure. We report a case of a cutaneous-limited self-regressing histiocytosis with a peculiar immunohistochemical profile (CD1a-positive and S100 protein-negative) that is not observed in any of the known cutaneous antigen-presenting cell or nowadays recognized neoplasm. This lesion is probably related to indeterminate dendritic cell tumors, but very few cases with such immunoprofile have been reported up-to-date, and their exact nosologic position and outcome remain to be clarified.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0193-1091 1533-0311
DOI:	10.1097/DAD.0b013e31827adc72