Synthesis and anti-MRSA Activity of Novel Cephalosporin Derivatives

• Published in: Tetrahedron Vol. 56; no. 31; pp. 5687 - 5698
• Main Authors: D'Andrea, Stan V., Bonner, Daniel, Bronson, Joanne J., Clark, Junius, Denbleyker, Ken, Fung-Tomc, Joan, Hoeft, Shelley E., Hudyma, Thomas W., Matiskella, John D., Miller, Raymond F., Misco, Peter F., Pucci, Michael, Sterzycki, Roman, Tsai, Yuan, Ueda, Yasutsuga, Wichtowski, John A., Singh, Janak, Kissick, Thomas P., North, Jeffery T., Pullockaran, Annie, Humora, Michael, Boyhan, Brenda, Vu, Truc, Fritz, Alan, Heikes, J., Fox, Rita, Godfrey, Jollie D., Perrone, Robert, Kaplan, Murray, Kronenthal, David, Mueller, Richard H.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 28-07-2000
• Subjects: 2,5-dichlorophenylthioacetamido; 2,6-dichloropyrid-4-ylthioacetamido; anti-MRSA activity; novel cephalosporins; 2,6-dichloropyrid-4-ylthioacetamido; 2,5-dichlorophenylthioacetamido; anti-MRSA activity; novel cephalosporins
• ISSN: 0040-4020; 1464-5416
• DOI: 10.1016/S0040-4020(00)00418-X

Cephalosporin derivatives containing a unique combination of lipophilic
C-7 sidechains and polar
C-3 thiopyridinium groups were synthesized and found to exhibit potent
anti-MRSA activity in vitro and in vivo. The optimum
C-7 sidechains utilized were 2,5-dichlorophenylthioacetamido and 2,6-dichloropyrid-4-ylthioacetamido. The
C-3 thiopyridinium rings were substituted at nitrogen with amino acid and pyruvic acid groups that were designed to confer aqueous solubility as required for IV formulation. This paper describes the characteristics of these novel cephalosporins and highlights synthetic methods developed to allow their practical, large-scale syntheses.