Chronic exposure to 2,2′-azobis-2-amidinopropane that induces intestinal damage and oxidative stress in larvae of Drosophila melanogaster
Embryonic development is exceptionally susceptible to pathogenic, chemistry and mechanical stressors as they can disrupt homeostasis, causing damage and impacted viability. Oxidative stress has the capacity to induce alterations and reshape the environment. However, the specific impacts of these oxi...
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| Published in: | Environmental toxicology and pharmacology Vol. 106; p. 104388 |
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| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
01-03-2024
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| Abstract | Embryonic development is exceptionally susceptible to pathogenic, chemistry and mechanical stressors as they can disrupt homeostasis, causing damage and impacted viability. Oxidative stress has the capacity to induce alterations and reshape the environment. However, the specific impacts of these oxidative stress-induced damages in the gastrointestinal tract of Drosophila melanogaster larvae have been minimally explored. This study used 2,2-azobis (2-amidinopropane) dihydrochloride (AAPH), a free radical generator, to investigate oxidative stress effects on Drosophila embryo development. The results showed that exposing Drosophila eggs to 30 mM AAPH during 1st instar larva, 2nd instar larva and 3rd instar larva stages significantly reduced hatching rates and pupal generation. It increased the activity of antioxidant enzymes and increased oxidative damage to proteins and MDA content, indicating severe oxidative stress. Morphological changes in 3rd individuals included decreased brush borders in enterocytes and reduced lipid vacuoles in trophocytes, essential fat bodies for insect metabolism. Immunostaining revealed elevated cleaved caspase 3, an apoptosis marker. This evidence validates the impact of oxidative stress toxicity and cell apoptosis following exposure, offering insights into comprehending the chemically induced effects of oxidative stress by AAPH on animal development.
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•A valuable tool to study human metabolism, tissue development, and oxidative stress in the developing gastrointestinal system.•Enables screening molecules for antioxidant and protective potential, paving way for therapeutic interventions.•AAPH-induced oxidative stress damages Drosophila gut development, leading to increased antioxidant activity and cell damage.•AAPH toxicity in development: Potential toxicity of AAPH in developing organisms. |
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| AbstractList | Embryonic development is exceptionally susceptible to pathogenic, chemistry and mechanical stressors as they can disrupt homeostasis, causing damage and impacted viability. Oxidative stress has the capacity to induce alterations and reshape the environment. However, the specific impacts of these oxidative stress-induced damages in the gastrointestinal tract of Drosophila melanogaster larvae have been minimally explored. This study used 2,2-azobis (2-amidinopropane) dihydrochloride (AAPH), a free radical generator, to investigate oxidative stress effects on Drosophila embryo development. The results showed that exposing Drosophila eggs to 30 mM AAPH during 1st instar larva, 2nd instar larva and 3rd instar larva stages significantly reduced hatching rates and pupal generation. It increased the activity of antioxidant enzymes and increased oxidative damage to proteins and MDA content, indicating severe oxidative stress. Morphological changes in 3rd individuals included decreased brush borders in enterocytes and reduced lipid vacuoles in trophocytes, essential fat bodies for insect metabolism. Immunostaining revealed elevated cleaved caspase 3, an apoptosis marker. This evidence validates the impact of oxidative stress toxicity and cell apoptosis following exposure, offering insights into comprehending the chemically induced effects of oxidative stress by AAPH on animal development. Embryonic development is exceptionally susceptible to pathogenic, chemistry and mechanical stressors as they can disrupt homeostasis, causing damage and impacted viability. Oxidative stress has the capacity to induce alterations and reshape the environment. However, the specific impacts of these oxidative stress-induced damages in the gastrointestinal tract of Drosophila melanogaster larvae have been minimally explored. This study used 2,2-azobis (2-amidinopropane) dihydrochloride (AAPH), a free radical generator, to investigate oxidative stress effects on Drosophila embryo development. The results showed that exposing Drosophila eggs to 30 mM AAPH during 1st instar larva, 2nd instar larva and 3rd instar larva stages significantly reduced hatching rates and pupal generation. It increased the activity of antioxidant enzymes and increased oxidative damage to proteins and MDA content, indicating severe oxidative stress. Morphological changes in 3rd individuals included decreased brush borders in enterocytes and reduced lipid vacuoles in trophocytes, essential fat bodies for insect metabolism. Immunostaining revealed elevated cleaved caspase 3, an apoptosis marker. This evidence validates the impact of oxidative stress toxicity and cell apoptosis following exposure, offering insights into comprehending the chemically induced effects of oxidative stress by AAPH on animal development. [Display omitted] •A valuable tool to study human metabolism, tissue development, and oxidative stress in the developing gastrointestinal system.•Enables screening molecules for antioxidant and protective potential, paving way for therapeutic interventions.•AAPH-induced oxidative stress damages Drosophila gut development, leading to increased antioxidant activity and cell damage.•AAPH toxicity in development: Potential toxicity of AAPH in developing organisms. |
| ArticleNumber | 104388 |
| Author | Mascarenhas, Fernanda Naves Araújo do Prado Duarte, Rener Mateus Francisco Borges, Ana Luiza Espindola, Foued Salmen Teixeira, Renata Roland Zanon, Renata Graciele Malta, Serena Mares Bittar, Vinicius Prado Vieira, Carlos Ueira |
| Author_xml | – sequence: 1 givenname: Rener Mateus Francisco surname: Duarte fullname: Duarte, Rener Mateus Francisco organization: Institute of Biotechnology, Federal University of Uberlandia, Uberlandia, MG, Brazil – sequence: 2 givenname: Serena Mares surname: Malta fullname: Malta, Serena Mares organization: Institute of Biotechnology, Federal University of Uberlandia, Uberlandia, MG, Brazil – sequence: 3 givenname: Fernanda Naves Araújo do Prado surname: Mascarenhas fullname: Mascarenhas, Fernanda Naves Araújo do Prado organization: Institute of Biomedicals Science, Federal University of Uberlandia, Uberlandia, MG, Brazil – sequence: 4 givenname: Vinicius Prado surname: Bittar fullname: Bittar, Vinicius Prado organization: Institute of Biotechnology, Federal University of Uberlandia, Uberlandia, MG, Brazil – sequence: 5 givenname: Ana Luiza surname: Borges fullname: Borges, Ana Luiza organization: Institute of Biotechnology, Federal University of Uberlandia, Uberlandia, MG, Brazil – sequence: 6 givenname: Renata Roland surname: Teixeira fullname: Teixeira, Renata Roland organization: Institute of Biotechnology, Federal University of Uberlandia, Uberlandia, MG, Brazil – sequence: 7 givenname: Renata Graciele surname: Zanon fullname: Zanon, Renata Graciele organization: Institute of Biomedicals Science, Federal University of Uberlandia, Uberlandia, MG, Brazil – sequence: 8 givenname: Carlos Ueira surname: Vieira fullname: Vieira, Carlos Ueira organization: Institute of Biotechnology, Federal University of Uberlandia, Uberlandia, MG, Brazil – sequence: 9 givenname: Foued Salmen surname: Espindola fullname: Espindola, Foued Salmen email: foued@ufu.br organization: Institute of Biotechnology, Federal University of Uberlandia, Uberlandia, MG, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38355029$$D View this record in MEDLINE/PubMed |
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| Keywords | Oxidative stress Gastrointestinal tract Developmental toxicity Drosophila melanogaster AAPH |
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