Habitat Radiomics Based on MRI for Predicting Platinum Resistance in Patients with High-Grade Serous Ovarian Carcinoma: A Multicenter Study

• Published in: Academic radiology Vol. 31; no. 6; pp. 2367 - 2380
• Main Authors: Bi, Qiu, Miao, Kun, Xu, Na, Hu, Faping, Yang, Jing, Shi, Wenwei, Lei, Ying, Wu, Yunzhu, Song, Yang, Ai, Conghui, Li, Haiming, Qiang, Jinwei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-06-2024
• Subjects: Adult; Aged; Antineoplastic Agents - therapeutic use; Contrast Media; Cystadenocarcinoma, Serous - diagnostic imaging; Cystadenocarcinoma, Serous - drug therapy; Deep Learning; Drug Resistance, Neoplasm; Feasibility Studies; Female; Habitat; Humans; Magnetic Resonance Imaging - methods; Middle Aged; MRI; Nomograms; Ovarian carcinoma; Ovarian Neoplasms - diagnostic imaging; Ovarian Neoplasms - drug therapy; Platinum resistance; Radiomics; Retrospective Studies; Platinum resistance; Habitat; Ovarian carcinoma; MRI; Radiomics
• ISSN: 1076-6332; 1878-4046; 1878-4046
• DOI: 10.1016/j.acra.2023.11.038

This study aims to explore the feasibility of MRI-based habitat radiomics for predicting response of platinum-based chemotherapy in patients with high-grade serous ovarian carcinoma (HGSOC), and compared to conventional radiomics and deep learning models.
A retrospective study was conducted on HGSOC patients from three hospitals. K-means algorithm was used to perform clustering on T2-weighted images (T2WI), contrast-enhanced T1-weighted images (CE-T1WI), and apparent diffusion coefficient (ADC) maps. After feature extraction and selection, the radiomics model, habitat model, and deep learning model were constructed respectively to identify platinum-resistant and platinum-sensitive patients. A nomogram was developed by integrating the optimal model and clinical independent predictors. The model performance and benefit was assessed using the area under the receiver operating characteristic curve (AUC), net reclassification index (NRI), and integrated discrimination improvement (IDI).
A total of 394 eligible patients were incorporated. Three habitats were clustered, a significant difference in habitat 2 (weak enhancement, high ADC values, and moderate T2WI signal) was found between the platinum-resistant and platinum-sensitive groups (P < 0.05). Compared to the radiomics model (0.640) and deep learning model (0.603), the habitat model had a higher AUC (0.710). The nomogram, combining habitat signatures with a clinical independent predictor (neoadjuvant chemotherapy), yielded a highest AUC (0.721) among four models, with positive NRI and IDI.
MRI-based habitat radiomics had the potential to predict response of platinum-based chemotherapy in patients with HGSOC. The nomogram combining with habitat signature had a best performance and good model gains for identifying platinum-resistant patients.