A mild and efficient synthesis of 4-aryl-quinolin-2(1 H)-ones via a tandem amidation/Knoevenagel condensation of 2-amino-benzophenones with esters or lactones

A mild and efficient synthesis of 4-aryl-quinolin-2(1 H)-ones via a tandem amidation/Knoevenagel condensation of 2-amino-benzophenones with esters or lactones

Using LiHMDS as the base, a tandem amidation/Knoevenagel condensation of 2-aminobenzophenones with α-methylene esters or lactones gives 4-aryl-quinolin-2(1 H)-ones in 65–96% yield. This method is mild, highly efficient, and amenable to scaleup. Graphic

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Bibliographic Details
Published in:Tetrahedron letters Vol. 44; no. 22; pp. 4271 - 4273
Main Authors: Wang, Jianji, Discordia, Robert P., Crispino, Gerard A., Li, Jun, Grosso, John A., Polniaszek, Richard, Truc, Vu C.
Format: Journal Article
Language:English
Published: Elsevier Ltd 26-05-2003
Online Access:Get full text
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Description
Summary:Using LiHMDS as the base, a tandem amidation/Knoevenagel condensation of 2-aminobenzophenones with α-methylene esters or lactones gives 4-aryl-quinolin-2(1 H)-ones in 65–96% yield. This method is mild, highly efficient, and amenable to scaleup. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(03)00889-X