ESR spectroscopy applied to the study of drugs radiosterilization: Case of three nitroimidazoles
The use of ionizing radiation for sterilization of pharmaceuticals is now a well esablished technology. In this paper, we examined the time stability at ambient conditions and higher temperatures of free radicals produced after the gamma irradiation of three nitroimidazoles: metronidazole, ornidazol...
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| Published in: | Applied radiation and isotopes Vol. 47; no. 11; pp. 1565 - 1568 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier Ltd
01-11-1996
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| Online Access: | Get full text |
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| Summary: | The use of ionizing radiation for sterilization of pharmaceuticals is now a well esablished technology. In this paper, we examined the time stability at ambient conditions and higher temperatures of free radicals produced after the gamma irradiation of three nitroimidazoles: metronidazole, ornidazole and ternidazole The bi-exponential model used to fit the decay curves showed, in major cases, two simultaneous phases: the first corresponding to a fast ‘pure’ exponential decay; and, a second corresponding to a slowly ‘quasi linear’ decay, possibly due to a solid diffusion mechanism. |
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| ISSN: | 0969-8043 1872-9800 |
| DOI: | 10.1016/S0969-8043(96)00208-4 |