Synthesis of new quinazoline-containing hydroxamic acids as potential HDAC/VEGFR inhibitors. Unusual rearrangements with pyrrolidone ring opening and dehydration of 3-N-hydroxyquinazoline fragment containing tetracycles
[Display omitted] Synthesis pathways were developed and new hydroxamic acids were obtained as potential inhibitors of HDAC/VEGFR2, including tetracycles containing quinazolinone fragment as a “cap”. Further biological testing of the obtained compounds will give an opportunity to estimate the real pr...
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| Published in: | Tetrahedron letters Vol. 60; no. 51; p. 151315 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier Ltd
19-12-2019
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| Abstract | [Display omitted]
Synthesis pathways were developed and new hydroxamic acids were obtained as potential inhibitors of HDAC/VEGFR2, including tetracycles containing quinazolinone fragment as a “cap”. Further biological testing of the obtained compounds will give an opportunity to estimate the real prospects of the chosen research direction. |
|---|---|
| AbstractList | [Display omitted]
Synthesis pathways were developed and new hydroxamic acids were obtained as potential inhibitors of HDAC/VEGFR2, including tetracycles containing quinazolinone fragment as a “cap”. Further biological testing of the obtained compounds will give an opportunity to estimate the real prospects of the chosen research direction. |
| ArticleNumber | 151315 |
| Author | Khachatryan, Derenik S. Kolotaev, Anton V. Osipov, Vasiliy N. Matevosyan, Karine R. |
| Author_xml | – sequence: 1 givenname: Anton V. surname: Kolotaev fullname: Kolotaev, Anton V. organization: The Federal State Unitary Enterprise «Institute of Chemical Reagents and High Purity Chemical Substances of National Research Centre «Kurchatov Institute», Bogorodsky val 3, Moscow 107076, Russia – sequence: 2 givenname: Karine R. surname: Matevosyan fullname: Matevosyan, Karine R. organization: D.Mendeleev University of Chemical Technology of Russia, Miusskaya square 9, Moscow 125047, Russia – sequence: 3 givenname: Vasiliy N. surname: Osipov fullname: Osipov, Vasiliy N. organization: The Federal State Unitary Enterprise «Institute of Chemical Reagents and High Purity Chemical Substances of National Research Centre «Kurchatov Institute», Bogorodsky val 3, Moscow 107076, Russia – sequence: 4 givenname: Derenik S. surname: Khachatryan fullname: Khachatryan, Derenik S. email: derenik-s@yandex.ru organization: The Federal State Unitary Enterprise «Institute of Chemical Reagents and High Purity Chemical Substances of National Research Centre «Kurchatov Institute», Bogorodsky val 3, Moscow 107076, Russia |
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| Cites_doi | 10.1021/jm100665z 10.1021/jm000352g 10.1021/jm400564j 10.1039/c2md00317a 10.3390/molecules23010024 10.1021/acs.jmedchem.6b01007 10.1016/j.bioorg.2017.12.007 10.1002/cbdv.201800027 10.1016/j.bmcl.2015.10.006 10.1158/1535-7163.MCT-12-1045 10.1021/acs.jmedchem.5b01342 10.3109/07388551.2015.1015957 10.2174/092986732501180122140757 10.1016/j.ejmech.2015.12.033 10.1016/S0960-894X(01)80244-4 10.1016/j.bmcl.2017.09.036 10.3390/molecules20033898 10.1101/cshperspect.a026831 10.1007/s11172-015-0875-9 10.1021/jm701274v 10.3390/ijms18071414 10.1248/cpb.c16-00386 10.1007/s11172-017-1852-2 10.1016/j.bmc.2016.09.009 10.2174/138945006777709593 10.1021/jm00312a007 10.1021/jm00273a034 10.1021/jm2013453 10.1021/acs.jmedchem.8b00050 10.1080/13543776.2017.1276565 |
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| Keywords | HDAC/VEGFR2 Hydroxamic acids Quinazoline Targeted therapy Hybrid inhibitors |
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Synthesis pathways were developed and new hydroxamic acids were obtained as potential inhibitors of HDAC/VEGFR2, including tetracycles... |
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| SubjectTerms | HDAC/VEGFR2 Hybrid inhibitors Hydroxamic acids Quinazoline Targeted therapy |
| Title | Synthesis of new quinazoline-containing hydroxamic acids as potential HDAC/VEGFR inhibitors. Unusual rearrangements with pyrrolidone ring opening and dehydration of 3-N-hydroxyquinazoline fragment containing tetracycles |
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