Synthesis of new quinazoline-containing hydroxamic acids as potential HDAC/VEGFR inhibitors. Unusual rearrangements with pyrrolidone ring opening and dehydration of 3-N-hydroxyquinazoline fragment containing tetracycles

Synthesis of new quinazoline-containing hydroxamic acids as potential HDAC/VEGFR inhibitors. Unusual rearrangements with pyrrolidone ring opening and dehydration of 3-N-hydroxyquinazoline fragment containing tetracycles

[Display omitted] Synthesis pathways were developed and new hydroxamic acids were obtained as potential inhibitors of HDAC/VEGFR2, including tetracycles containing quinazolinone fragment as a “cap”. Further biological testing of the obtained compounds will give an opportunity to estimate the real pr...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 60; no. 51; p. 151315
Main Authors: Kolotaev, Anton V., Matevosyan, Karine R., Osipov, Vasiliy N., Khachatryan, Derenik S.
Format: Journal Article
Language:English
Published: Elsevier Ltd 19-12-2019
Subjects:
HDAC/VEGFR2
Hybrid inhibitors
Hydroxamic acids
Quinazoline
Targeted therapy
HDAC/VEGFR2
Hydroxamic acids
Quinazoline
Targeted therapy
Hybrid inhibitors
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Description
Summary:[Display omitted] Synthesis pathways were developed and new hydroxamic acids were obtained as potential inhibitors of HDAC/VEGFR2, including tetracycles containing quinazolinone fragment as a “cap”. Further biological testing of the obtained compounds will give an opportunity to estimate the real prospects of the chosen research direction.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2019.151315