Bioactive constituents of the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. (Melianthaceae)
A new xanthone glycoside (1) and a new bufadienolide (2) named bersamaxanthoside and bersamabufadienolide, respectively, together with seventeen known compounds (3–19) were isolated from the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. Their structures were elucidated based on the...
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| Published in: | Phytochemistry letters Vol. 59; pp. 53 - 58 |
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| Main Authors: | , , , , , , , , , , , |
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01-02-2024
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| Abstract | A new xanthone glycoside (1) and a new bufadienolide (2) named bersamaxanthoside and bersamabufadienolide, respectively, together with seventeen known compounds (3–19) were isolated from the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. Their structures were elucidated based on their spectroscopic data. The extract, fractions and compounds were assessed for their cytotoxicity on the cervix carcinoma cell line KB-3–1. The MeOH extract and the EtOAc and n-BuOH soluble fractions exhibited weak activity with IC50 values of 0.085, 0.084 and 0.075 mg/mL, respectively. The other tested samples were inactive. In addition, some of the isolates were tested for their DPPH radical scavenging activity and only compounds 1, 11–13, 16, and 17 displayed antioxidant properties with IC50 values ranging from 2.9 to 38.1 µg/mL.
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•A new xanthone glycoside and a new bufadienolide from Bersama abyssinica stem bark.•A lignan and a benzoquinone are firstly reported form the genus Bersama.•The cytotoxicity and DPPH radical scavenging activities of extracts and isolates. |
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| AbstractList | A new xanthone glycoside (1) and a new bufadienolide (2) named bersamaxanthoside and bersamabufadienolide, respectively, together with seventeen known compounds (3–19) were isolated from the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. Their structures were elucidated based on their spectroscopic data. The extract, fractions and compounds were assessed for their cytotoxicity on the cervix carcinoma cell line KB-3–1. The MeOH extract and the EtOAc and n-BuOH soluble fractions exhibited weak activity with IC50 values of 0.085, 0.084 and 0.075 mg/mL, respectively. The other tested samples were inactive. In addition, some of the isolates were tested for their DPPH radical scavenging activity and only compounds 1, 11–13, 16, and 17 displayed antioxidant properties with IC50 values ranging from 2.9 to 38.1 µg/mL.
[Display omitted]
•A new xanthone glycoside and a new bufadienolide from Bersama abyssinica stem bark.•A lignan and a benzoquinone are firstly reported form the genus Bersama.•The cytotoxicity and DPPH radical scavenging activities of extracts and isolates. |
| Author | Nono, Raymond Ngansop Lenta, Bruno Ndjakou Tsafack, Vanessa Charnele Stammler, Hans-Georg Nkeng-Efouet-Alango, Pépin Neumann, Beate Kouam, Siméon Fogué Chouna, Jean Rodolphe Tabekoueng, Georges Bellier Sewald, Norbert Dongmo, Appolinaire Kene Bankeu, Jean Jules Kezetas |
| Author_xml | – sequence: 1 givenname: Vanessa Charnele surname: Tsafack fullname: Tsafack, Vanessa Charnele organization: Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon – sequence: 2 givenname: Appolinaire Kene surname: Dongmo fullname: Dongmo, Appolinaire Kene organization: Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon – sequence: 3 givenname: Raymond Ngansop surname: Nono fullname: Nono, Raymond Ngansop organization: Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon – sequence: 4 givenname: Georges Bellier surname: Tabekoueng fullname: Tabekoueng, Georges Bellier organization: Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157 Douala, Douala, Cameroon – sequence: 5 givenname: Beate surname: Neumann fullname: Neumann, Beate organization: Department of Chemistry, Inorganic and Structural Chemistry, Bielefeld University, P.O. Box 100131, Bielefeld 33501, Germany – sequence: 6 givenname: Hans-Georg surname: Stammler fullname: Stammler, Hans-Georg organization: Department of Chemistry, Inorganic and Structural Chemistry, Bielefeld University, P.O. Box 100131, Bielefeld 33501, Germany – sequence: 7 givenname: Jean Jules Kezetas surname: Bankeu fullname: Bankeu, Jean Jules Kezetas organization: Department of Chemistry, Faculty of Science, The University of Bamenda-Bambili, P.O. Box 39, Bamenda, Cameroon – sequence: 8 givenname: Siméon Fogué surname: Kouam fullname: Kouam, Siméon Fogué organization: Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon – sequence: 9 givenname: Pépin surname: Nkeng-Efouet-Alango fullname: Nkeng-Efouet-Alango, Pépin organization: Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon – sequence: 10 givenname: Bruno Ndjakou surname: Lenta fullname: Lenta, Bruno Ndjakou organization: Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon – sequence: 11 givenname: Norbert orcidid: 0000-0002-0309-2655 surname: Sewald fullname: Sewald, Norbert organization: Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, P.O. Box 100131, Bielefeld 33501, Germany – sequence: 12 givenname: Jean Rodolphe surname: Chouna fullname: Chouna, Jean Rodolphe email: jean.chouna@univ-dschang.org organization: Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon |
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| Keywords | Bersama abyssinica Melianthaceae Cytotoxicity Bufadienolide Xanthone glycoside Antioxidant |
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| SubjectTerms | Antioxidant Bersama abyssinica Bufadienolide Cytotoxicity Melianthaceae Xanthone glycoside |
| Title | Bioactive constituents of the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. (Melianthaceae) |
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