Results of a prospective, randomized, double blind comparison of the efficacy and the safety of sequential ciprofloxacin (intravenous/oral)+metronidazole (intravenous/oral) with ceftriaxone (intravenous)+metronidazole (intravenous/oral) for the treatment of intra-abdominal infections

The efficacy and the safety of sequential intravenous/oral (i.v./p.o.) ciprofloxacin (CIPX) plus i.v./p.o. metronidazole (MTR) was compared with i.v. ceftriaxone (CTRX) plus i.v./p.o. MTR in the treatment of complicated intra-abdominal infections. One hundred and forty two patients received study me...

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Bibliographic Details
Published in:	International journal of antimicrobial agents Vol. 21; no. 1; pp. 49 - 57
Main Authors:	Starakis, I, Karravias, D, Asimakopoulos, C, Kolaras, P, Nikolaidis, P, Harlaftis, N, Skoutelis, A, Bassaris, H
Format:	Journal Article
Language:	English
Published:	London Elsevier B.V 2003 Amsterdam Elsevier New York, NY
Subjects:	Abdominal Abscess - drug therapy Adult Aged Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Infections - drug therapy Biological and medical sciences Ceftriaxone Ceftriaxone - administration & dosage Ceftriaxone - adverse effects Ciprofloxacin Ciprofloxacin - administration & dosage Ciprofloxacin - adverse effects Double-Blind Method Drug Therapy, Combination Female Humans Intestinal Perforation - drug therapy Intra-abdominal infections Male Medical sciences Metronidazole Metronidazole - administration & dosage Metronidazole - adverse effects Middle Aged Peritonitis - drug therapy Pharmacology. Drug treatments Prospective Studies Sequential treatment Intra-abdominal infections Sequential treatment Metronidazole Ceftriaxone Ciprofloxacin Human Nitro compound Imidazole derivatives Drug combination Intravenous administration Toxicity β-Lactams Oral administration Controlled therapeutic trial Abdomen Infection Antibiotic Chemotherapy Cephalosporin derivatives Fluoroquinolone derivatives Randomization Treatment Bacteriosis Clinical trial Antibacterial agent Quinolone derivatives
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