N-Halosuccinimides mediated deprotection of cysteine-S protecting groups for one-pot regioselective synthesis of disulfide bonds in peptides under mild aqueous conditions

[Display omitted] •Two disulfide bonds were synthesized regioselectively by an one-pot approach.•Good yield was achieved under mild conditions.•Formation of a hydrolytic stable halosulfonium cation plays a critical role in the reactions. Cysteine (Cys) with side chain protected by groups acetamidome...

Full description

Bibliographic Details

Published in:	Tetrahedron letters Vol. 120; p. 154459
Main Authors:	Xing, Yueyue, Wang, Yafang, Ma, Dongying, Shen, Shigang, Song, Changying, Zhang, Nan, Bo, Tianyu, Shi, Tiesheng, Huo, Shuying
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 28-04-2023
Subjects:	Deprotection Multiple disulfide bonds N-halosuccinimides One-pot synthesis Peptides One-pot synthesis N-halosuccinimides Multiple disulfide bonds Peptides Deprotection
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!