Micellar extractions with anionic surfactant SDS and the mixture of SDS/OSAS for determination lovastatin in river samples

• Published in: Journal of molecular liquids Vol. 187; pp. 320 - 325
• Main Authors: Hryniewicka, Marta, Starczewska, Barbara, Syperek, Izabela
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-11-2013
• Subjects: Drugs; Lovastatin; Micellar extraction; Water samples; Drugs; Lovastatin; Water samples; Micellar extraction
• ISSN: 0167-7322; 1873-3166
• DOI: 10.1016/j.molliq.2013.08.012

The potential of the micellar extractions techniques for the preconcentration of lovastatin (LOV) was studied. The analyte has created micelle with anionic surfactant sodium dodecyl sulfate (SDS). Moreover, we have noticed that it is possible to isolate LOV using a binary mixture of SDS and 1-octanesulfonic acid sodium salt (OSAS). Therefore, two independent procedures were described in this study. Here we demonstrate the optimum analytical conditions for LOV assay such as pH of solution, concentration of surfactants, centrifugation time and electrolyte type. The linear calibration curves were obtained. The method range for LOV-SDS was of 10−6mol·L−1 to 5×10−5mol·L−1 with detection and quantification limits of 0.69×10−6mol·L−1 and 1.11×10−6mol·L−1, respectively, and the range for LOV-SDS/OSAS was of 10−6mol·L−1 to 6×10−5mol·L−1, with detection and quantification limits of 1.38×10−6 and 2.10×10−6mol·L−1. The recoveries of the method using SDS surfactant were 93.5–101% and for the mixture of SDS/OSAS were 85–107.5%. The proposed preconcentration methods after validation were successfully applied to spectrophotometric and chromatographic determination of LOV in water samples from the local river.
•Lovastatin has created micelle with anionic surfactant sodium dodecyl sulfate (SDS).•The mixture of SDS and OSAS is possible for isolation this drug from water samples.•The addition of a suitable salt (NaCl and CaCl2) is required.•Concentration of surfactants, pH of solution, centrifugation time were studied.•The surfactant-rich phases were diluted in 10mL of methanol.