Monte Carlo calculations of dose distribution for intramural delivery of radioisotopes using a direct injection balloon catheter

• Published in: Cardiovascular radiation medicine Vol. 3; no. 1; pp. 44 - 48
• Main Authors: Kassing, William M, McGoron, Anthony J, Thomas, Stephen R, Elson, Howard R, Pipes, David W
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-01-2002
• Subjects: Adult; Beta Particles - therapeutic use; BRACHYTHERAPY; Catheterization - instrumentation; COMPUTERIZED SIMULATION; CORONARIES; Coronary; Coronary Restenosis - prevention & control; Direct injection; Dose-Response Relationship, Radiation; Drug Delivery Systems; Electrons - therapeutic use; Gamma Rays - therapeutic use; Humans; INDIUM 111; Infiltrator; INJECTION; Injections; Intravascular brachytherapy; IODINE 123; Monte Carlo; MONTE CARLO METHOD; PHOSPHORUS 32; Photons - therapeutic use; Radiation; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSES; Radioisotopes - administration & dosage; RADIOLOGY AND NUCLEAR MEDICINE; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Reference Values; Restenosis; RHENIUM 186; RHENIUM 188; SAMARIUM 153; TECHNETIUM 99; Treatment Outcome; Restenosis; Intravascular brachytherapy; Monte Carlo; Infiltrator; Radiation; Coronary; Direct injection
• ISSN: 1522-1865
• DOI: 10.1016/S1522-1865(02)00142-7

Purpose: A unique method of delivering radiation dose to the coronary vessel wall to prevent restenosis is by direct injection of radioactive compounds into the vessel wall using a specially designed angioplasty balloon catheter. The radiation dose distribution resulting from such intramural delivery was investigated using Monte Carlo simulations.
Materials and methods: The radioisotope source distribution was modeled for two configurations within the vessel wall: (1) uniform to a depth of 0.5 mm and (2) confined to discrete pools surrounding the delivery injection ports. Monte Carlo MCNP4B computer simulations were utilized to estimate the associated radiation dose distribution for the following radioisotopes:
188Re,
186Re,
32P,
153Sm,
111In,
123I, and
99mTc.
Results: For the uniform case where the radioisotopes are distributed uniformly to the depth of 0.5 mm into the vessel wall, an essentially constant radiation dose is delivered within the source distribution. Outside of the source volume, the dose falls off at a rate depending on the emission properties of the particular radioisotope. The nonuniform case involving discrete pools of activity showed the dose distribution being confined largely to the regions surrounding the delivery ports with significant regions between these ports receiving very little dose.
Conclusions: Direct injection of selected radioisotopes into the arterial wall appears to represent a potentially effective method for delivering radiation dose for the prevention of restenosis. Sufficiently high doses may be obtained from relatively low activity and the dose falls off rapidly outside of the target area for certain radioisotopes.