In vivo effect of vitamin E on serum and tissue glycoprotein levels in perchloroethylene induced cytotoxicity

• Published in: Molecular and cellular biochemistry Vol. 144; no. 1; pp. 13 - 18
• Main Authors: Ebrahim, A.S, Gopalakrishnan, R, Murugesan, A, Sakthisekaran, D
• Format: Journal Article
• Language: English
• Published: Netherlands 09-03-1995
• Subjects: Animals; Antioxidants - metabolism; blood serum; cytotoxicity; Free Radicals - metabolism; glycoproteins; Glycoproteins - blood; Glycoproteins - metabolism; Kidney - cytology; Kidney - drug effects; Kidney - metabolism; kidneys; liver; Liver - cytology; Liver - drug effects; Liver - metabolism; Male; Monosaccharides - blood; Monosaccharides - metabolism; N-Acetylneuraminic Acid; organochlorine compounds; protein content; Proteins - metabolism; Rats; Rats, Wistar; Sialic Acids - blood; Sialic Acids - metabolism; Tetrachloroethylene - administration & dosage; Tetrachloroethylene - toxicity; vitamin E; Vitamin E - pharmacology
• ISSN: 0300-8177; 1573-4919
• DOI: 10.1007/BF00926735

The antioxidant efficacy of vitamin E on Perchloroethylene (PER) induced cytotoxicity has been studied in rats. Feeding PER to rats for 42 days using sesame oil as vehicle alters total protein and protein bound carbohydrate components in liver and kidney of experimental animals. Supplementation of vitamin E prevented the changes observed in total protein and protein bound carbohydrate components of PER administered rats. Histopathological studies also show the effectiveness of vitamin E on PER administered rats in protecting the cellular architecture of liver and kidney from PER induced cytotoxicity.