Microbial reduction of ethyl 2-oxo-4-phenylbutyrate. Searching for R-enantioselectivity. New access to the enalapril like ACE inhibitors

Microbial reduction of ethyl 2-oxo-4-phenylbutyrate. Searching for R-enantioselectivity. New access to the enalapril like ACE inhibitors

Herein, different microorganisms were tested in the enantioselective reduction of ethyl 2-oxo-4-phenylbutyrate in aqueous medium for the preparation of ethyl ( R)-2-hydroxy-4-phenylbutyrate, a key intermediate in the production of angiotensin converting enzyme (ACE) inhibitors. The use of Pichia ang...

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Bibliographic Details
Published in:Tetrahedron: asymmetry Vol. 17; no. 8; pp. 1186 - 1188
Main Authors: de Lacerda, Paulo S. Bergo, Ribeiro, Joyce Benzaquem, Leite, Selma G.F., Ferrara, Maria Antonieta, Coelho, Ricardo B., Bon, Elba P.S., da Silva Lima, Edson Luiz, Antunes, O.A.C.
Format: Journal Article
Language:English
Published: Elsevier Ltd 18-04-2006
Online Access:Get full text
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Summary:Herein, different microorganisms were tested in the enantioselective reduction of ethyl 2-oxo-4-phenylbutyrate in aqueous medium for the preparation of ethyl ( R)-2-hydroxy-4-phenylbutyrate, a key intermediate in the production of angiotensin converting enzyme (ACE) inhibitors. The use of Pichia angusta led to the ( R)-enantiomer in 81% ee.
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2006.04.008