Liposomes loaded with lipophilic derivative of closo-carborane as a potential boron delivery system for boron neutron capture therapy of tumors

• Published in: Mendeleev communications Vol. 31; no. 5; pp. 659 - 661
• Main Authors: Tsygankova, Alphiya R., Gruzdev, Dmitry A., Kanygin, Vladimir V., Ya. Guselnikova, Tatiana, Telegina, Angelina A., Kasatova, Anna I., Kichigin, Aleksandr I., Levit, Galina L., Mechetina, Ludmila V., Mukhamadiyarov, Rinat A., Razumov, Ivan A., Solovieva, Olga I., Yu. Volkova, Olga, Ponomarev, Andrey A., Krasnov, Victor P., Zavjalov, Evgenii L.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-09-2021
• Subjects: amide; biodistribution; BNCT; closo-carborane; liposomes; toxicity; U87 tumor model; toxicity; biodistribution; BNCT; amide; liposomes; closo-carborane; U87 tumor model
• ISSN: 0959-9436
• DOI: 10.1016/j.mencom.2021.09.022

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Liposomes encapsulated with lipophilic derivative of 1,2-dicarba-closo-dodecaborane have been obtained and tested for toxicity to glioblastoma U87 cells and biodistribution on a U87MG xenograft mouse model. The liposomes are able to penetrate the tumor and provide boron concentration up to 1.5 mmmmg g–1 with tumor-to-muscle ratio up to 2.4.