Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy

Pathogenesis in tauopathies involves the accumulation of tau in the brain and progressive synapse loss accompanied by cognitive decline. Pathological tau is found at synapses, and it promotes synaptic dysfunction and memory deficits. The specific role of toxic tau in disrupting the molecular network...

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Bibliographic Details
Published in:	BioEssays Vol. 39; no. 4
Main Authors:	Tracy, Tara E, Gan, Li
Format:	Journal Article
Language:	English
Published:	United States 01-04-2017
Subjects:	Acetylation Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Animals Brain - metabolism Brain - physiopathology Disease Models, Animal Humans Memory Disorders - metabolism Protein Processing, Post-Translational Synapses - metabolism tau Proteins - metabolism Tauopathies - metabolism Tauopathies - physiopathology KIBRA acetylation tau synaptic plasticity Alzheimer's disease long-term potentiation
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