The grapefruit polyphenol naringenin inhibits multiple cardiac ion channels

Drinking fresh grapefruit juice is associated with a significant prolongation of the QT segment on the electrocardiogram (ECG) in healthy volunteers. Among the prominent polyphenols contained in citrus fruits and primarily in grapefruit, the flavonoid naringenin is known to be a blocker of the human...

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Bibliographic Details
Published in:	Naunyn-Schmiedeberg's archives of pharmacology Vol. 395; no. 6; pp. 735 - 740
Main Authors:	Sanson, Camille, Boukaiba, Rachid, Houtmann, Sylvie, Maizières, Magali-Anne, Fouconnier, Sophie, Partiseti, Michel, Bohme, G. Andrees
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-06-2022 Springer Nature B.V
Subjects:	Action potential Animals Arrhythmia Arrhythmias, Cardiac Biomedical and Life Sciences Biomedicine Brief Communication Calcium channels (voltage-gated) Citrus fruits Citrus paradisi EKG ERG1 Potassium Channel Ether-A-Go-Go Potassium Channels - physiology Flavanones - pharmacology Flavonoids Heart Humans Ion Channels Juices Mammalian cells Mammals Naringenin Neurosciences Patch-Clamp Techniques Pharmacology/Toxicology Polyphenols Polyphenols - pharmacology Potassium channels (inwardly-rectifying) Potassium channels (voltage-gated) Risk assessment Sodium channels (voltage-gated) Ventricle Ion channels Automated patch-clamp electrophysiology CiPA paradigm Arrhythmogenic food Cardiac safety Torsade de Pointe
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