A well-differentiated liposarcoma co-existent with leiomyoma

• Published in: Vojnosanitetski pregled Vol. 61; no. 5; pp. 565 - 568
• Main Authors: Stojsic, Zorica, Bacetic, Dragoljub, Radevic, Bozina, Vasiljevic, Jovan
• Format: Journal Article
• Language: English
• Published: Serbia Military Health Department, Ministry of Defance, Serbia 2004
• Subjects: Female; Humans; leiomyoma; Leiomyoma - pathology; liposarcoma; Liposarcoma - pathology; Middle Aged; Neoplasms, Multiple Primary - pathology; retroperitoneal neoplasms; Retroperitoneal Neoplasms - pathology; soft tissue neoplasms
• ISSN: 0042-8450; 2406-0720
• DOI: 10.2298/VSP0405565S

The coexistence of a well-differentiated liposarcoma (atypical lipomatous tumor) and benign smooth muscle component in a single soft tissue neoplasm is extremely rare.
Histologic and immunohistochemical characteristics of tumor, which represented the recurrence of a retroperitoneal atypical lipoma in a 50-year-old female patient are presented in this paper. The tumor represented the recurrence of a retroperitoneal atypical lipoma. Lipomatous component consisted of a mixture of lipoma-like and sclerosing variant of well-differentiated liposarcoma. Characteristically, the heterologous smooth muscle differentiation was manifested as a macroscopically visible nodular growth in the form of a leiomyoma within the adipocytic component. It consisted of intersecting fascicles of spindle cells, which lacked mitoses and significant atypia, and were immunopositive for smooth muscle markers.
This case of well-differentiated liposarcoma with benign smooth muscle is the first reported tumor of retroperitoneal localization. It is also the first one to exhibit the heterologous smooth muscle component as a distinct leiomyoma.