Whole-body 18F-fluorodeoxyglucose positron emission tomography/computed tomography images before and after chemotherapy for Kaposi sarcoma and highly active antiretrovirus therapy

• Published in: Japanese Journal of Radiology Vol. 28; no. 10; pp. 759 - 762
• Main Authors: Morooka, Miyako, Ito, Kimiteru, Kubota, Kazuo, Minamimoto, Ryogo, Shida, Yoshitaka, Hasuo, Kanehiro, Ito, Tateki, Tasato, Daisuke, Honda, Haruhito, Teruya, Katsuji, Kikuchi, Yoshimi, Ohtomo, Kuni
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01-12-2010; Springer Nature B.V
• Subjects: Aged; Antiretroviral Therapy, Highly Active; Case Report; Fatal Outcome; Fluorodeoxyglucose F18; HIV Infections - complications; Humans; Imaging; Male; Medicine; Medicine & Public Health; Multiple Organ Failure; Nuclear Medicine; Pancreatitis - complications; Positron-Emission Tomography - methods; Radiology; Radiopharmaceuticals; Radiotherapy; Sarcoma, Kaposi - complications; Sarcoma, Kaposi - diagnosis; Sarcoma, Kaposi - drug therapy; Tomography, X-Ray Computed - methods; Whole Body Imaging - methods; FDG; Kaposi sarcoma; AIDS; PET
• ISSN: 1867-1071; 1862-5274; 1867-108X
• DOI: 10.1007/s11604-010-0481-6

Kaposi sarcoma is an acquired immunodeficiency syndrome-related disease that mainly involves the skin, gastrointestinal gut, and lungs. Whole-body
18
F-fluorodeoxyglucose-positron emission tomography and computed tomography (FDG-PET/CT) scanning is useful for simultaneous detection of multiple lesions of Kaposi sarcoma. We present a 67-year-old man with a history of infection with human immunodeficiency virus who presented with numerous cutaneous lesions. FDG-PET/CT images showed lesions in the skin, lung, and lymph nodes. The gastrointestinal lesions were detected using gastric fiberscopy (GF) and colon fiberscopy (CF). After Kaposi sarcoma therapy, the uptake in the lesions of the skin, lung, and lymph nodes decreased, but new lesions were detected in the pancreas and lumbar spine. He had pancreatitis and
Candida
spondilitis. Whole-body FDG-PET/CT is useful for detecting lesions and determining the extension to which the disease has spread, adding the gastrointestinal lesions by GF and CF. After therapy, FDG-PET/CT can be used to demonstrate which lesions remain active and to determine the overall response to treatment. In this case, we show how useful FDG-PET/CT is and how difficult it is to treat Kaposi sarcoma.