Effect of Aerobic Training on Peak Oxygen Uptake Among Seniors Aged 70 or Older: A Meta-Analysis of Randomized Controlled Trials

• Published in: Rejuvenation research Vol. 21; no. 4; p. 341
• Main Authors: Bouaziz, Walid, Kanagaratnam, Lukshe, Vogel, Thomas, Schmitt, Elise, Dramé, Moustapha, Kaltenbach, Georges, Geny, Bernard, Lang, Pierre Olivier
• Format: Journal Article
• Language: English
• Published: United States 01-08-2018
• Subjects: Aged; Cohort Studies; Exercise - physiology; Female; Humans; Male; Oxygen - metabolism; Oxygen Consumption; Randomized Controlled Trials as Topic; older adults; VO2peak; aerobic training; health benefits; endurance training
• ISSN: 1557-8577
• DOI: 10.1089/rej.2017.1988

Older adults undergo a progressive decline in cardiorespiratory fitness and functional capacity. This lower peak oxygen uptake (VO
) level is associated with increased risk of frailty, dependency, loss of autonomy, and mortality from all causes. Regular physical activity and particularly aerobic training (AT) have been shown to contribute to better and healthy aging. We conducted a meta-analysis to measure the exact benefit of AT on VO
in seniors aged 70 years or older. A comprehensive, systematic database search for articles was performed in Embase, Medline, PubMed Central, Science Direct, Scopus, and Web of Science using key words. Two reviewers independently assessed interventional studies for potential inclusion. Ten randomized controlled trials (RCTs) were included totaling 348 seniors aged 70 years or older. Across the trials, no high risk of bias was measured and all considered open-label arms for controls. With significant heterogeneity between the RCTs (all p < 0.001), pooled analyses were computed for VO
. Not only was VO
found significantly higher in the training group compared to controls (mean difference [MD] = 1.56; 95% confidence interval [CI]: 0.90-2.23) in pooled analysis of the 10 RCTs but also when the analysis was adjusted on the participants' health statuses. MD among healthy and unhealthy seniors were, respectively, 1.72 (95% CI: 0.34-3.10) and 1.47 (95% CI: 0.60-2.34). This meta-analysis confirms the AT-associated benefits on VO
in healthy and unhealthy seniors.