6-Imino-1,3-oxazines: a new class of hepatoprotectants

6-Imino-1,3-oxazines: a new class of hepatoprotectants

A convenient synthesis of polysubstituted 6-imino-1,3-oxazines (3,5,9) from corresponding ketene dithioacetals has been described and their conversion to pyrimidin-6-one (6) and pyrazolo[3,4- d]pyrimidine (8) studied. The oxazines synthesized, have shown a significant hepatoprotective activity. Poly...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters Vol. 5; no. 7; pp. 695 - 698
Main Authors: Ram, Vishnu Ji, Nath, Mahendra, Patnaik, G.K.
Format: Journal Article
Language:English
Published: Elsevier Ltd 06-04-1995
Online Access:Get full text
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Summary:A convenient synthesis of polysubstituted 6-imino-1,3-oxazines (3,5,9) from corresponding ketene dithioacetals has been described and their conversion to pyrimidin-6-one (6) and pyrazolo[3,4- d]pyrimidine (8) studied. The oxazines synthesized, have shown a significant hepatoprotective activity. Polysubstituted 6-imino-1,3-oxazines are synthesized as hepatoprotectants and transformed to pyrimidin-6-one (6) and pyrazolo[3,4-d]pyrimidine (8).
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(95)00096-C