Effect of sustained mesenteric nerve stimulation on intestinal oxygenation in developing swine

• Published in: The American journal of physiology Vol. 260; no. 2 Pt 1; pp. G333 - G339
• Main Authors: Nowicki, P T, Miller, C E, Hayes, J R
• Format: Journal Article
• Language: English
• Published: United States 01-02-1991
• Subjects: Aging; Animals; Animals, Newborn; Electric Stimulation; Homeostasis; Intestines - blood supply; Intestines - innervation; Mesenteric Arteries - growth & development; Mesenteric Arteries - innervation; Mesenteric Veins - growth & development; Mesenteric Veins - innervation; Oxygen - blood; Oxygen Consumption; Partial Pressure; Regional Blood Flow; Splanchnic Circulation - physiology; Swine; Vascular Resistance; Vasoconstriction
• ISSN: 0002-9513
• DOI: 10.1152/ajpgi.1991.260.2.G333

The effects of sustained mesenteric nerve stimulation on intestinal oxygenation were determined in 3- and 35-day-old swine. Studies were conducted in pentobarbital-anesthetized animals during free-flow or constant-flow perfusion. Square-wave stimuli sufficient to induce maximal resistance vessel constriction were applied to postganglionic periarterial mesenteric nerves and each stimulation was sustained until measured variables reached steady state. When vascular resistance data were analyzed without data transformation, autoregulatory escape of intestinal vascular resistance was more complete in 3- than in 35-day-old animals when the escape process was complete; however, expression of these data as escape indexes revealed a similar degree of escape in both age groups. In 35-day-old animals, (a-v)O2 increased during sustained nerve stimulation under free-flow conditions; under constant-flow conditions, (a-v)O2, 86Rb extraction, and capillary permeability-surface area product were lower at completion of the escape process compared with baseline. In 3-day-old swine, these variables remained unchanged from baseline. Intestinal O2 uptake was compromised by sustained nerve stimulation, and this effect was similar in both age groups. We conclude that sustained nerve stimulation reduces intestinal oxygenation to a similar degree in 3- and 35-day-old swine. It is important to note, however, that the response of 3-day-old swine may be dissimilar from that which occurs during immediate postnatal life; indeed, the intestinal hemodynamic response of swine less than or equal to 1 day old should not be extrapolated from the response of 3-day-old animals.