General methodology for synthesis of fused tricyclic oxazino-2-quinolones under phase-transfer catalyzed conditions

General methodology for synthesis of fused tricyclic oxazino-2-quinolones under phase-transfer catalyzed conditions

[Display omitted] A one-pot synthesis of substituted oxazino-2-quinolones is described. The cornerstone of this methodology involves PTC catalyzed addition of an ethylene dihalide to a quinol to generate the corresponding O-alkylated intermediate in situ followed by ring closing and subsequent forma...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 45; no. 51; pp. 9361 - 9364
Main Authors: Dutta, Rajat, Mandal, Debayan, Panda, Nilendu, Mondal, Nirup B., Banerjee, Sukdeb, Kumar, Shrabanti, Weber, Manuela, Luger, Peter, Sahu, Niranjan P.
Format: Journal Article
Language:English
Published: Elsevier Ltd 13-12-2004
Online Access:Get full text
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Summary:[Display omitted] A one-pot synthesis of substituted oxazino-2-quinolones is described. The cornerstone of this methodology involves PTC catalyzed addition of an ethylene dihalide to a quinol to generate the corresponding O-alkylated intermediate in situ followed by ring closing and subsequent formation of a carbonyl group in the oxazinoquinolone in a one-pot sequence.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.10.134