The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation
In the era of precision medicine, treatments that target specific modifiable characteristics of high-risk patients have the potential to lower further the residual risk of atherosclerotic cardiovascular events. Correction of atherogenic dyslipidemia, however, remains a major unmet clinical need. Ele...
Saved in:
| Published in: | Cardiovascular diabetology Vol. 18; no. 1; p. 71 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
BioMed Central
04-06-2019
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | In the era of precision medicine, treatments that target specific modifiable characteristics of high-risk patients have the potential to lower further the residual risk of atherosclerotic cardiovascular events. Correction of atherogenic dyslipidemia, however, remains a major unmet clinical need. Elevated plasma triglycerides, with or without low levels of high-density lipoprotein cholesterol (HDL-C), offer a key modifiable component of this common dyslipidemia, especially in insulin resistant conditions such as type 2 diabetes mellitus. The development of selective peroxisome proliferator-activated receptor alpha modulators (SPPARMα) offers an approach to address this treatment gap. This Joint Consensus Panel appraised evidence for the first SPPARMα agonist and concluded that this agent represents a novel therapeutic class, distinct from fibrates, based on pharmacological activity, and, importantly, a safe hepatic and renal profile. The ongoing PROMINENT cardiovascular outcomes trial is testing in 10,000 patients with type 2 diabetes mellitus, elevated triglycerides, and low levels of HDL-C whether treatment with this SPPARMα agonist safely reduces residual cardiovascular risk. |
|---|---|
| AbstractList | In the era of precision medicine, treatments that target specific modifiable characteristics of high-risk patients have the potential to lower further the residual risk of atherosclerotic cardiovascular events. Correction of atherogenic dyslipidemia, however, remains a major unmet clinical need. Elevated plasma triglycerides, with or without low levels of high-density lipoprotein cholesterol (HDL-C), offer a key modifiable component of this common dyslipidemia, especially in insulin resistant conditions such as type 2 diabetes mellitus. The development of selective peroxisome proliferator-activated receptor alpha modulators (SPPARMα) offers an approach to address this treatment gap. This Joint Consensus Panel appraised evidence for the first SPPARMα agonist and concluded that this agent represents a novel therapeutic class, distinct from fibrates, based on pharmacological activity, and, importantly, a safe hepatic and renal profile. The ongoing PROMINENT cardiovascular outcomes trial is testing in 10,000 patients with type 2 diabetes mellitus, elevated triglycerides, and low levels of HDL-C whether treatment with this SPPARMα agonist safely reduces residual cardiovascular risk. In the era of precision medicine, treatments that target specific modifiable characteristics of high-risk patients have the potential to lower further the residual risk of atherosclerotic cardiovascular events. Correction of atherogenic dyslipidemia, however, remains a major unmet clinical need. Elevated plasma triglycerides, with or without low levels of high-density lipoprotein cholesterol (HDL-C), offer a key modifiable component of this common dyslipidemia, especially in insulin resistant conditions such as type 2 diabetes mellitus. The development of selective peroxisome proliferator-activated receptor alpha modulators (SPPARMα) offers an approach to address this treatment gap. This Joint Consensus Panel appraised evidence for the first SPPARMα agonist and concluded that this agent represents a novel therapeutic class, distinct from fibrates, based on pharmacological activity, and, importantly, a safe hepatic and renal profile. The ongoing PROMINENT cardiovascular outcomes trial is testing in 10,000 patients with type 2 diabetes mellitus, elevated triglycerides, and low levels of HDL-C whether treatment with this SPPARMα agonist safely reduces residual cardiovascular risk.In the era of precision medicine, treatments that target specific modifiable characteristics of high-risk patients have the potential to lower further the residual risk of atherosclerotic cardiovascular events. Correction of atherogenic dyslipidemia, however, remains a major unmet clinical need. Elevated plasma triglycerides, with or without low levels of high-density lipoprotein cholesterol (HDL-C), offer a key modifiable component of this common dyslipidemia, especially in insulin resistant conditions such as type 2 diabetes mellitus. The development of selective peroxisome proliferator-activated receptor alpha modulators (SPPARMα) offers an approach to address this treatment gap. This Joint Consensus Panel appraised evidence for the first SPPARMα agonist and concluded that this agent represents a novel therapeutic class, distinct from fibrates, based on pharmacological activity, and, importantly, a safe hepatic and renal profile. The ongoing PROMINENT cardiovascular outcomes trial is testing in 10,000 patients with type 2 diabetes mellitus, elevated triglycerides, and low levels of HDL-C whether treatment with this SPPARMα agonist safely reduces residual cardiovascular risk. |
| ArticleNumber | 71 |
| Author | Packard, Chris J Wahli, Walter Ponte-Negretti, Carlos I Plutzky, Jorge Ceska, Richard Shimano, Hitoshi Stock, Jane K Ridker, Paul M Pradhan, Aruna Aikawa, Masanori McPherson, Ruth Tybjærg-Hansen, Anne Krempf, Michel Hermans, Michel P Tartar, André Ray, Kausik K Su, Ta-Chen Kodama, Tatsuhiko Aguilar-Salinas, Carlos Tomlinson, Brian Corsini, Alberto Barter, Philip J Ishibashi, Shun Fruchart, Jean-Charles Zambon, Alberto Duriez, Patrick Karpe, Fredrik Amarenco, Pierre Després, Jean-Pierre Lim, Soo Eckel, Robert H Ginsberg, Henry N Al Rasadi, Khalid Susekov, Andrey V Ezhov, Marat V Farnier, Michel Taskinen, Marja-Riitta Yamashita, Shizuya Sadikot, Shaukat Valensi, Paul Santos, Raul D Vrablík, Michal Koenig, Wolfgang Libby, Peter Nuñez-Cortes, Jesus Millan Tokgözoğlu, Lale S Watts, Gerald F Reiner, Željko Tenenbaum, Alexander Nordestgaard, Børge G Yokote, Koutaro Ogawa, Hisao Sritara, Piyamitr Ruscica, Massimiliano Lorenzatti, Alberto J |
| Author_xml | – sequence: 1 givenname: Jean-Charles surname: Fruchart fullname: Fruchart, Jean-Charles email: jean-Charles.fruchart@r3i.org organization: R3i Foundation, Picassoplatz 8, 4010, Basel, Switzerland. jean-Charles.fruchart@r3i.org – sequence: 2 givenname: Raul D surname: Santos fullname: Santos, Raul D organization: Hospital Israelita Albert Einstein, and Lipid Clinic, Heart Institute (InCor) University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil – sequence: 3 givenname: Carlos surname: Aguilar-Salinas fullname: Aguilar-Salinas, Carlos organization: Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Mexico – sequence: 4 givenname: Masanori surname: Aikawa fullname: Aikawa, Masanori organization: Center for Interdisciplinary Cardiovascular Sciences and Center for Excellence in Vascular Biology, Division of Cardiovascular Medicine and Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA – sequence: 5 givenname: Khalid surname: Al Rasadi fullname: Al Rasadi, Khalid organization: Department of Clinical Biochemistry, Sultan Qaboos University Hospital, Muscat, Oman – sequence: 6 givenname: Pierre surname: Amarenco fullname: Amarenco, Pierre organization: Department of Neurology and Stroke Center, Paris-Diderot-Sorbonne University, Paris, France – sequence: 7 givenname: Philip J surname: Barter fullname: Barter, Philip J organization: Lipid Research Group, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia – sequence: 8 givenname: Richard surname: Ceska fullname: Ceska, Richard organization: IIIrd Dept Int. Med, Center for Preventive Cardiology, 3rd Internal Medicine Clinic, University General Hospital and Charles University, Prague, Czech Republic – sequence: 9 givenname: Alberto surname: Corsini fullname: Corsini, Alberto organization: Department of Pharmacological and Biomolecular Sciences, Università Degli Studi di Milano, Milan, Italy – sequence: 10 givenname: Jean-Pierre surname: Després fullname: Després, Jean-Pierre organization: Centre de recherche sur les soins et les services de première ligne-Université Laval du CIUSSS de la Capitale-Nationale, Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, QC, Canada – sequence: 11 givenname: Patrick surname: Duriez fullname: Duriez, Patrick organization: INSERM, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, University of Lille, Faculty of Pharmacy, University of Lille, UDSL, Lille, France – sequence: 12 givenname: Robert H surname: Eckel fullname: Eckel, Robert H organization: Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA – sequence: 13 givenname: Marat V surname: Ezhov fullname: Ezhov, Marat V organization: Laboratory of Lipid Disorders, National Cardiology Research Center, Moscow, Russian Federation – sequence: 14 givenname: Michel surname: Farnier fullname: Farnier, Michel organization: Lipid Clinic, Point Médical and Department of Cardiology, CHU Dijon-Bourgogne, Dijon, France – sequence: 15 givenname: Henry N surname: Ginsberg fullname: Ginsberg, Henry N organization: Columbia University Vagelos College of Physicians and Surgeons, New York, USA – sequence: 16 givenname: Michel P surname: Hermans fullname: Hermans, Michel P organization: Division of Endocrinology and Nutrition, Cliniques Universitaires St-Luc and Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium – sequence: 17 givenname: Shun surname: Ishibashi fullname: Ishibashi, Shun organization: Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan – sequence: 18 givenname: Fredrik surname: Karpe fullname: Karpe, Fredrik organization: OCDEM, University of Oxford and the NIHR Oxford Biomedical Research Centre, OUH Foundation Trust, Churchill Hospital, Oxford, UK – sequence: 19 givenname: Tatsuhiko surname: Kodama fullname: Kodama, Tatsuhiko organization: Laboratory for System Biology and Medicine Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan – sequence: 20 givenname: Wolfgang surname: Koenig fullname: Koenig, Wolfgang organization: Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany – sequence: 21 givenname: Michel surname: Krempf fullname: Krempf, Michel organization: Department of Endocrinology, Metabolic diseases and Nutrition, G and R Laennec Hospital, Nantes, France – sequence: 22 givenname: Soo surname: Lim fullname: Lim, Soo organization: Department of Internal Medicine, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam, Republic of Korea – sequence: 23 givenname: Alberto J surname: Lorenzatti fullname: Lorenzatti, Alberto J organization: Cardiology Department, Córdoba Hospital, Córdoba, Argentina – sequence: 24 givenname: Ruth surname: McPherson fullname: McPherson, Ruth organization: Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Canada – sequence: 25 givenname: Jesus Millan surname: Nuñez-Cortes fullname: Nuñez-Cortes, Jesus Millan organization: Instituto de Investigaciones Sanitarias Gregorio Marañón, Madrid, Spain – sequence: 26 givenname: Børge G surname: Nordestgaard fullname: Nordestgaard, Børge G organization: Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark – sequence: 27 givenname: Hisao surname: Ogawa fullname: Ogawa, Hisao organization: National Cerebral and Cardiovascular Center, Suita, Osaka, Japan – sequence: 28 givenname: Chris J surname: Packard fullname: Packard, Chris J organization: Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK – sequence: 29 givenname: Jorge surname: Plutzky fullname: Plutzky, Jorge organization: Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA – sequence: 30 givenname: Carlos I surname: Ponte-Negretti fullname: Ponte-Negretti, Carlos I organization: Unidad de Prevención Cardiometabólica Cardiocob. Servicio de Cardiología Hospital el Pino Santiago de Chile, Sociedad Inter Americana de Cardiología SIAC Chairman Cardiovascular Prevention Comite, Santiago de Chile, Chile – sequence: 31 givenname: Aruna surname: Pradhan fullname: Pradhan, Aruna organization: Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA – sequence: 32 givenname: Kausik K surname: Ray fullname: Ray, Kausik K organization: Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London, UK – sequence: 33 givenname: Željko surname: Reiner fullname: Reiner, Željko organization: Department of Internal Medicine, University Hospital Centre Zagreb, School of Medicine, Zagreb University, Kispaticeva 12, Zagreb, Croatia – sequence: 34 givenname: Paul M surname: Ridker fullname: Ridker, Paul M organization: Division of Cardiovascular Medicine and Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA – sequence: 35 givenname: Massimiliano surname: Ruscica fullname: Ruscica, Massimiliano organization: Department of Pharmacological and Biomolecular Sciences, Università Degli Studi di Milano, Milan, Italy – sequence: 36 givenname: Shaukat surname: Sadikot fullname: Sadikot, Shaukat organization: Department of Endocrinology/Diabetology, Jaslok Hospital and Research Centre, Mumbai, India – sequence: 37 givenname: Hitoshi surname: Shimano fullname: Shimano, Hitoshi organization: Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan – sequence: 38 givenname: Piyamitr surname: Sritara fullname: Sritara, Piyamitr organization: Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand – sequence: 39 givenname: Jane K surname: Stock fullname: Stock, Jane K organization: R3i Foundation, Picassoplatz 8, 4010, Basel, Switzerland – sequence: 40 givenname: Ta-Chen surname: Su fullname: Su, Ta-Chen organization: Departments of Internal Medicine and Environmental and Occupational Medicine, National Taiwan University; Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan – sequence: 41 givenname: Andrey V surname: Susekov fullname: Susekov, Andrey V organization: Faculty of Clinical Pharmacology and Therapeutics, Academy for Postgraduate Continuous Medical Education, Moscow, Russian Federation – sequence: 42 givenname: André surname: Tartar fullname: Tartar, André organization: Faculté de Pharmacie de Lille, Lille, France – sequence: 43 givenname: Marja-Riitta surname: Taskinen fullname: Taskinen, Marja-Riitta organization: Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki and Clinical Research Institute, HUCH Ltd., Helsinki, Finland – sequence: 44 givenname: Alexander surname: Tenenbaum fullname: Tenenbaum, Alexander organization: Cardiac Rehabilitation Institute, Sheba Medical Center, 5265601, Tel Hashomer, Israel – sequence: 45 givenname: Lale S surname: Tokgözoğlu fullname: Tokgözoğlu, Lale S organization: Department of Cardiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey – sequence: 46 givenname: Brian surname: Tomlinson fullname: Tomlinson, Brian organization: Department of Medicine & Theraputics, The Chinese University of Hong Kong, Hong Kong, Hong Kong – sequence: 47 givenname: Anne surname: Tybjærg-Hansen fullname: Tybjærg-Hansen, Anne organization: The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev, Denmark – sequence: 48 givenname: Paul surname: Valensi fullname: Valensi, Paul organization: Department of Endocrinology, Diabetology and Nutrition, Jean-Verdier Hospital (AP-HP), Paris 13 University, Sorbonne Paris Cité, CRNH-IdF, CINFO, 93140, Bondy, France – sequence: 49 givenname: Michal surname: Vrablík fullname: Vrablík, Michal organization: 3rd Department of Medicine, 1st Faculty of Medicine of Charles University and General University Hospital in Prague, Prague, Czech Republic – sequence: 50 givenname: Walter surname: Wahli fullname: Wahli, Walter organization: Institut National de La Recherche Agronomique (INRA), UMR1331 ToxAlim, Toulouse, France – sequence: 51 givenname: Gerald F surname: Watts fullname: Watts, Gerald F organization: Lipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, School of Medicine, University of Western Australia, Perth, Australia – sequence: 52 givenname: Shizuya surname: Yamashita fullname: Yamashita, Shizuya organization: Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan – sequence: 53 givenname: Koutaro surname: Yokote fullname: Yokote, Koutaro organization: Department of Endocrinology, Hematology and Gerontology, Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan – sequence: 54 givenname: Alberto surname: Zambon fullname: Zambon, Alberto organization: Department of Medicine-DIMED, University of Padua, Padua, Italy – sequence: 55 givenname: Peter surname: Libby fullname: Libby, Peter organization: Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31164165$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVUstu1DAUDaiIPmDJgg3ycmYRyI3zmi6QoqqFkYqoZsra8tg3HdPEDrZT6Gf1R_gm7E5blY1f95xzHz6HyZ42GpPkPWQfAZrqk4N8QWmawSLNmqpI65fJARR1meZNke09O-8nh879zDKomwpeJ_sUoCqgKg9evLvcInHYo_DqBsmI1vxRzgzhaE2vOrTcG5vyGOYeJbEocAxPhPfjlpPByKmPEDJbX1y0q29_7-Zk5JZLdTUcE2F0hE-8J53lA_429ppwLYnfBuURJ68EGY1H7VXAHJM2UhxqNznifMg4hFDgmiFSyFJ7tJp7ZXSAt1HFONHHVTmyNkKhvyWzZbueP6YhK3RKxgpWyl2Hm5xE5ActFZLetz1bUTUnZ2bS8l77TfKq473Dtw_7UfLj7PTy5Gt6_v3L8qQ9TwXNCp9uoChEWQGtGthshAzDzXnXLUpJaYaFoFLkSLsqlxXUgJBvsKMdD7SmBhpCR8nnne44bQaUIvRqec9GqwZub5nhiv0f0WrLrswNq8piQcsyCMweBKz5NaHzbFBOYN9zjWZyLKdQLur48QEKO6gIw3IWu6c0kLFoJ7azEwt2YtFOLHI-PK_vifHoH_oP2eXQZg |
| Cites_doi | 10.1056/NEJMoa1001282 10.1161/01.CIR.103.2.207 10.1016/j.ceb.2015.02.003 10.1161/01.CIR.99.24.3125 10.1161/CIRCULATIONAHA.117.032235 10.1161/CIRCOUTCOMES.115.002104 10.1056/NEJMoa1609581 10.1016/j.jphs.2017.02.003 10.1056/NEJMoa0706628 10.1016/j.atherosclerosissup.2018.04.471 10.1056/NEJMc1006407 10.1074/jbc.M401028200 10.1016/j.atherosclerosis.2016.03.003 10.1194/jlr.M088419 10.1016/j.atherosclerosis.2019.01.029 10.1161/ATVBAHA.116.307601 10.1016/j.bbrc.2018.03.135 10.1161/CIRCULATIONAHA.107.713438 10.1007/s11883-016-0614-1 10.1161/01.ATV.8.4.421 10.3390/ijms19072148 10.1161/CIRCULATIONAHA.118.035289 10.1161/01.CIR.60.3.473 10.3390/ijms20030706 10.1016/j.ijcard.2017.05.059 10.1016/S0140-6736(07)61607-9 10.1161/CIRCRESAHA.117.308903 10.1001/jama.2017.0972 10.1016/S0140-6736(07)60527-3 10.1210/er.2018-00064 10.1016/S0140-6736(18)31992-5 10.1161/01.CIR.103.2.213 10.1111/jdi.12621 10.2337/dc17-1589 10.1056/NEJMoa1707914 10.1073/pnas.0538015100 10.1097/MEG.0000000000001183 10.1056/NEJMoa1801174 10.1016/j.pcad.2018.06.004 10.1093/eurheartj/ehr112 10.1002/j.1460-2075.1992.tb05072.x 10.1016/j.jacl.2017.10.006 10.1093/eurheartj/ehu505 10.1016/j.bmcl.2007.05.066 10.2337/db18-1153-p 10.1016/j.tem.2015.09.007 10.1016/j.amjcard.2008.10.002 10.1056/NEJMoa1107579 10.1373/clinchem.2014.234146 10.1001/jamacardio.2017.5205 10.1016/j.diabet.2015.02.002 10.1373/clinchem.2016.270876 10.1016/S2213-8587(17)30313-3 10.1016/j.jacl.2018.11.008 10.1007/s00125-010-1951-1 10.1161/01.RES.0000127122.22685.0A 10.1002/hep.28431 10.1093/eurheartj/ehx144 10.1074/jbc.274.45.32048 10.1016/j.jacc.2017.02.030 10.1016/j.metabol.2017.02.013 10.1016/j.atherosclerosis.2016.02.029 10.1093/eurheartj/eht055 10.1093/eurheartj/ehw106 10.1161/CIRCULATIONAHA.117.032318 10.1161/01.ATV.0000054194.78240.45 10.5551/jat.44412 10.1373/clinchem.2015.253757 10.1016/j.atherosclerosis.2011.07.019 10.1161/ATVBAHA.116.308834 10.5551/jat.28720 10.1007/s00125-005-0125-z 10.1093/eurheartj/ehw152 10.1016/j.atherosclerosis.2017.03.032 10.1038/nrendo.2017.119 10.1093/eurheartj/ehx662 10.1373/clinchem.2018.294926 10.1136/gutjnl-2017-313884 10.1080/17425255.2018.1483337 10.1161/01.CIR.80.3.719 10.1016/j.mrfmmm.2005.02.028 10.1056/NEJMoa1615664 10.1111/dom.13537 10.1093/eurheartj/ehu500 10.1111/jdi.12845 10.1016/j.atherosclerosis.2009.03.008 10.1038/srep42477 10.1517/14740338.5.1.145 10.1056/NEJMoa1308027 10.1161/CIR.0b013e3182160726 10.1373/clinchem.2017.279463 10.4158/EP15672.GLSUPPL 10.1161/01.CIR.101.24.2777 10.1186/1475-2840-12-82 10.5551/jat.39693 10.1093/eurheartj/ehw272 10.1016/j.atherosclerosis.2013.09.020 10.1038/384039a0 10.1038/ncpcardio1278 10.1016/j.ahj.2018.09.011 10.1016/j.jacc.2007.10.038 10.1161/01.ATV.15.4.534 10.1056/NEJMoa1812792 10.1016/j.tem.2012.05.001 10.1161/CIRCULATIONAHA.104.475673 10.1016/j.jacc.2018.11.003 10.1056/NEJMoa1206797 10.1056/NEJMoa1307095 10.1056/NEJMoa1001288 10.1001/jama.298.3.299 10.2337/dc11-1811 10.1001/jama.298.3.309 10.1097/MOL.0000000000000372 10.1016/j.jacl.2012.05.002 10.1016/j.pharmthera.2013.11.008 10.1001/jamacardio.2016.4828 10.1016/S0140-6736(17)32409-1 10.1097/MCG.0000000000000925 10.1007/s12020-015-0838-9 10.1161/JAHA.118.008740 10.1016/j.amjcard.2009.04.008 10.1056/NEJMoa1510926 10.1186/s12872-017-0591-5 10.1161/CIRCULATIONAHA.113.002529 10.1093/eurheartj/ehs271 10.1016/j.jacc.2015.03.544 10.1016/S0140-6736(12)60312-2 10.3389/fimmu.2018.01605 10.1056/NEJMoa1507652 10.1161/01.CIR.102.16.1886 10.1016/S0140-6736(14)61177-6 10.1001/jama.297.12.1362 10.1016/j.cmet.2016.01.006 10.1016/j.crvasa.2014.02.002 10.1001/jama.2009.1619 10.1016/j.jacl.2018.06.010 10.1016/S0083-6729(00)60018-3 10.1016/j.jacc.2012.08.1026 10.1161/ATVBAHA.115.305614 10.1161/01.CIR.96.6.1737 10.1186/s12933-017-0602-y |
| ContentType | Journal Article |
| Copyright | The Author(s) 2019 |
| Copyright_xml | – notice: The Author(s) 2019 |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
| DOI | 10.1186/s12933-019-0864-7 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1475-2840 |
| ExternalDocumentID | 10_1186_s12933_019_0864_7 31164165 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Review |
| GroupedDBID | --- -5E -5G -A0 -BR 0R~ 29B 2WC 3V. 53G 5GY 5VS 6J9 7X7 88E 8FI 8FJ AAFWJ AAJSJ ABDBF ABUWG ACGFO ACGFS ACIHN ACIWK ACPRK ACRMQ ADBBV ADINQ ADRAZ ADUKV AEAQA AENEX AFKRA AFPKN AFRAH AHBYD AHMBA AHYZX ALIPV ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS BAPOH BAWUL BCNDV BENPR BFQNJ BMC BPHCQ BVXVI C24 C6C CCPQU CGR CS3 CUY CVF DIK DU5 E3Z EAD EAP EAS EBD EBLON EBS ECM EIF EJD EMB EMK EMOBN ESX F5P FRP FYUFA GROUPED_DOAJ GX1 HMCUK HYE IAO IHR INH INR ITC KQ8 M1P M48 M~E NPM O5R O5S OK1 P2P PGMZT PIMPY PQQKQ PROAC PSQYO RBZ RNS ROL RPM RSV SMD SOJ SV3 TR2 TUS UKHRP W2D WOQ WOW XSB AAYXX CITATION 7X8 5PM |
| ID | FETCH-LOGICAL-c304t-b144c5613681bbcd8612aff95d330e4c3dc2e3f62d6171e12bef3fab1487132e3 |
| IEDL.DBID | RPM |
| ISSN | 1475-2840 |
| IngestDate | Tue Sep 17 21:16:59 EDT 2024 Sat Oct 26 02:12:27 EDT 2024 Thu Sep 12 16:39:09 EDT 2024 Sat Nov 02 12:28:50 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Atherogenic dyslipidemia SPPARMalpha Selective peroxisome proliferator-activated receptor alpha modulator Residual cardiovascular risk Inflammation Pemafibrate (K-877) Triglycerides Diabetes PROMINENT Remnant cholesterol Visceral obesity |
| Language | English |
| License | Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c304t-b144c5613681bbcd8612aff95d330e4c3dc2e3f62d6171e12bef3fab1487132e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549355/ |
| PMID | 31164165 |
| PQID | 2315970017 |
| PQPubID | 23479 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6549355 proquest_miscellaneous_2315970017 crossref_primary_10_1186_s12933_019_0864_7 pubmed_primary_31164165 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-06-04 |
| PublicationDateYYYYMMDD | 2019-06-04 |
| PublicationDate_xml | – month: 06 year: 2019 text: 2019-06-04 day: 04 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: London |
| PublicationTitle | Cardiovascular diabetology |
| PublicationTitleAlternate | Cardiovasc Diabetol |
| PublicationYear | 2019 |
| Publisher | BioMed Central |
| Publisher_xml | – name: BioMed Central |
| References | OO Olubamwo (864_CR5) 2018; 30 BP Neve (864_CR105) 2001; 103 CI Ponte-Negretti (864_CR27) 2017; 243 E Araki (864_CR136) 2018; 41 MH Davidson (864_CR7) 2006; 5 AV Khera (864_CR77) 2017; 317 I Matsuba (864_CR143) 2018 SK Nilsson (864_CR76) 2011; 219 JJ Kastelein (864_CR49) 2008; 117 P Libby (864_CR42) 2015; 36 C Schlein (864_CR121) 2016; 23 RD Santos (864_CR24) 2019; 282 N Hounslow (864_CR140) 2018; 32 DB Zilversmit (864_CR72) 1979; 60 PM Ridker (864_CR19) 2017; 377 864_CR150 B Staels (864_CR108) 2008; 5 K Yokote (864_CR142) 2018; 32 H Iwata (864_CR127) 2014; 115 AIM-HIGH Investigators (864_CR37) 2011; 365 LA Adams (864_CR149) 2017; 66 JC Mychaleckyj (864_CR8) 2012; 35 M Yokoyama (864_CR92) 2007; 369 J Crosby (864_CR80) 2014; 371 BA Ference (864_CR14) 2017; 38 V Krishnan (864_CR111) 2000; 60 AB Jørgensen (864_CR79) 2014; 371 864_CR145 PR Devchand (864_CR104) 1996; 384 PP Toth (864_CR55) 2018; 7 GG Schwartz (864_CR38) 2012; 367 N Marx (864_CR99) 2004; 94 T Jernberg (864_CR12) 2015; 36 D Steinberg (864_CR71) 1989; 80 JD Brunzell (864_CR33) 2008; 31 T Maki (864_CR130) 2017; 71 Y Yamamoto (864_CR116) 2018; 499 MF Piepoli (864_CR6) 2016; 37 N Hennuyer (864_CR126) 2016; 249 LA Pennacchio (864_CR75) 2003; 23 A Tikka (864_CR61) 2016; 52 S Kersten (864_CR62) 2017; 13 MP Bonaca (864_CR17) 2018; 137 JD Tugwood (864_CR98) 1992; 11 GG Schwartz (864_CR50) 2015; 65 864_CR2 SE Nissen (864_CR114) 2007; 297 JS Lewis (864_CR112) 2005; 591 Y Sasaki (864_CR151) 2018; 67 AM Lincoff (864_CR40) 2017; 376 NO Stitziel (864_CR82) 2016; 374 I Pineda Torra (864_CR101) 2002; 16 JJP Kastelein (864_CR137) 2015; 36 The Emerging Risk Factors Collaboration (864_CR34) 2009; 302 T Aung (864_CR93) 2018; 3 W Wahli (864_CR107) 2012; 23 FM Sacks (864_CR13) 2014; 129 HPS2-THRIVE Collaborative Group (864_CR39) 2013; 34 O Ziouzenkova (864_CR58) 2003; 100 EY Chew (864_CR147) 2010; 363 M Adiels (864_CR57) 2006; 49 I Doycheva (864_CR148) 2018; 52 Y Handelsman (864_CR88) 2015; 21 AC Keech (864_CR146) 2007; 370 H Arai (864_CR133) 2018; 25 S Ishibashi (864_CR134) 2018; 12 M-R Taskinen (864_CR25) 2016; 18 DL Bhatt (864_CR94) 2018; 380 A Angajala (864_CR110) 2018; 9 HN Ginsberg (864_CR53) 2010; 362 BG Nordestgaard (864_CR65) 1988; 8 AD Pradhan (864_CR144) 2018; 206 FE Dewey (864_CR81) 2016; 374 JD Brown (864_CR60) 2007; 115 N Marx (864_CR103) 1999; 99 H Arai (864_CR135) 2017; 261 R Puri (864_CR51) 2016; 36 GG Schwartz (864_CR16) 2018; 379 S Yamashita (864_CR139) 2018; 12 MS Hedrington (864_CR10) 2018; 14 KV Patel (864_CR21) 2018; 137 S Raza-Iqbal (864_CR119) 2015; 22 R Klempfner (864_CR52) 2016; 9 FM Sacks (864_CR90) 2010; 363 BG Nordestgaard (864_CR64) 1995; 15 BG Nordestgaard (864_CR78) 1997; 96 MS Sabatine (864_CR18) 2017; 5 Y Yamazaki (864_CR115) 2007; 17 AM Jepsen (864_CR70) 2016; 62 BG Nordestgaard (864_CR43) 2016; 37 O Faergeman (864_CR48) 2009; 104 K Yokote (864_CR141) 2019; 20 ZM Younossi (864_CR4) 2016; 64 TM Davis (864_CR9) 2011; 54 ME Piché (864_CR22) 2018; 61 H Gronemeyer (864_CR97) 1995; 2 JC Fruchart (864_CR113) 2013; 12 A Varbo (864_CR68) 2013; 61 MB Elam (864_CR91) 2017; 2 A Augustus (864_CR59) 2004; 279 FM Sacks (864_CR84) 2000; 102 SEJ Hansen (864_CR74) 2018 A Varbo (864_CR131) 2018; 64 M Miller (864_CR47) 2008; 51 Y Honda (864_CR129) 2017; 7 P Delerive (864_CR100) 1999; 274 W Fan (864_CR28) 2018 BK Lauridsen (864_CR23) 2018; 39 JC Fruchart (864_CR11) 2008; 102 NO Stitziel (864_CR83) 2017; 69 AJ Vallejo-Vaz (864_CR66) 2018; 138 SJ Bernelot Moens (864_CR73) 2017; 37 M Miller (864_CR41) 2011; 123 JP Halcox (864_CR31) 2017; 17 GA Nichols (864_CR54) 2019; 21 JC Fruchart (864_CR95) 2009; 205 L Shi (864_CR109) 2015; 33 A Kharitonenkov (864_CR120) 2015; 26 S Bansal (864_CR46) 2007; 298 PP Tóth (864_CR30) 2012; 6 A Varbo (864_CR69) 2015; 61 C Zheng (864_CR85) 2013; 34 MJ Chapman (864_CR26) 2011; 32 N Bougarne (864_CR102) 2018; 39 SS Anand (864_CR20) 2018; 391 BG Nordestgaard (864_CR56) 2014; 384 B Nussbaumerová (864_CR32) 2014; 56 SM Grundy (864_CR87) 2018 L Juntti-Berggren (864_CR86) 2017; 28 P Joseph (864_CR1) 2017; 121 NCD Countdown 2030 collaborators (864_CR3) 2018; 392 M Araki (864_CR128) 2018; 19 A Besseiche (864_CR117) 2015; 41 AL Catapano (864_CR89) 2016; 37 JC Fruchart (864_CR118) 2017; 16 K Takei (864_CR123) 2017; 8 PJ Barter (864_CR36) 2007; 357 BF Voight (864_CR35) 2012; 380 MA Austin (864_CR44) 2000; 101 K Takei (864_CR125) 2017; 133 S Ishibashi (864_CR132) 2016; 249 N Marx (864_CR106) 2001; 103 Ž Reiner (864_CR29) 2013; 231 BG Nordestgaard (864_CR45) 2007; 298 A Varbo (864_CR67) 2014; 141 M Sairyo (864_CR124) 2018; 25 MS Sabatine (864_CR15) 2017; 376 CN Brocker (864_CR96) 2018; 59 KL Ong (864_CR122) 2017; 63 J Borén (864_CR63) 2015; 35 JJP Kastelein (864_CR138) 2015; 36 |
| References_xml | – volume: 362 start-page: 1563 year: 2010 ident: 864_CR53 publication-title: N Eng J Med. doi: 10.1056/NEJMoa1001282 contributor: fullname: HN Ginsberg – volume: 103 start-page: 207 year: 2001 ident: 864_CR105 publication-title: Circulation doi: 10.1161/01.CIR.103.2.207 contributor: fullname: BP Neve – volume: 33 start-page: 125 year: 2015 ident: 864_CR109 publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2015.02.003 contributor: fullname: L Shi – volume: 115 start-page: e86 year: 2014 ident: 864_CR127 publication-title: Circ Res. contributor: fullname: H Iwata – volume: 99 start-page: 3125 year: 1999 ident: 864_CR103 publication-title: Circulation doi: 10.1161/01.CIR.99.24.3125 contributor: fullname: N Marx – volume: 36 start-page: 1048 year: 2015 ident: 864_CR138 publication-title: Eur Heart J. contributor: fullname: JJP Kastelein – volume: 137 start-page: 338 year: 2018 ident: 864_CR17 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.032235 contributor: fullname: MP Bonaca – volume: 9 start-page: 100 year: 2016 ident: 864_CR52 publication-title: Circ Cardiovasc Qual Outcomes. doi: 10.1161/CIRCOUTCOMES.115.002104 contributor: fullname: R Klempfner – volume: 2 start-page: 1173 year: 1995 ident: 864_CR97 publication-title: Protein Profile. contributor: fullname: H Gronemeyer – volume: 376 start-page: 1933 year: 2017 ident: 864_CR40 publication-title: N Engl J Med doi: 10.1056/NEJMoa1609581 contributor: fullname: AM Lincoff – volume: 133 start-page: 214 year: 2017 ident: 864_CR125 publication-title: J Pharmacol Sci. doi: 10.1016/j.jphs.2017.02.003 contributor: fullname: K Takei – volume: 357 start-page: 2109 year: 2007 ident: 864_CR36 publication-title: N Engl J Med doi: 10.1056/NEJMoa0706628 contributor: fullname: PJ Barter – volume: 32 start-page: 155 year: 2018 ident: 864_CR140 publication-title: Atheroscler Suppl contributor: fullname: N Hounslow – volume: 32 start-page: 155 year: 2018 ident: 864_CR142 publication-title: Atheroscler Suppl doi: 10.1016/j.atherosclerosissup.2018.04.471 contributor: fullname: K Yokote – volume: 363 start-page: 692 year: 2010 ident: 864_CR90 publication-title: N Engl J Med doi: 10.1056/NEJMc1006407 contributor: fullname: FM Sacks – volume: 279 start-page: 25050 year: 2004 ident: 864_CR59 publication-title: J Biol Chem doi: 10.1074/jbc.M401028200 contributor: fullname: A Augustus – volume: 249 start-page: 200 year: 2016 ident: 864_CR126 publication-title: Atherosclerosis. doi: 10.1016/j.atherosclerosis.2016.03.003 contributor: fullname: N Hennuyer – volume: 59 start-page: 2140 year: 2018 ident: 864_CR96 publication-title: J Lipid Res doi: 10.1194/jlr.M088419 contributor: fullname: CN Brocker – volume: 282 start-page: 110 year: 2019 ident: 864_CR24 publication-title: Atherosclerosis. doi: 10.1016/j.atherosclerosis.2019.01.029 contributor: fullname: RD Santos – volume: 36 start-page: 2220 year: 2016 ident: 864_CR51 publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.116.307601 contributor: fullname: R Puri – volume: 499 start-page: 239 year: 2018 ident: 864_CR116 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2018.03.135 contributor: fullname: Y Yamamoto – volume: 117 start-page: 3002 year: 2008 ident: 864_CR49 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.107.713438 contributor: fullname: JJ Kastelein – volume: 18 start-page: 59 year: 2016 ident: 864_CR25 publication-title: Curr Atheroscler Rep. doi: 10.1007/s11883-016-0614-1 contributor: fullname: M-R Taskinen – volume: 8 start-page: 421 year: 1988 ident: 864_CR65 publication-title: Arteriosclerosis. doi: 10.1161/01.ATV.8.4.421 contributor: fullname: BG Nordestgaard – volume: 19 start-page: E2148 year: 2018 ident: 864_CR128 publication-title: Int J Mol Sci. doi: 10.3390/ijms19072148 contributor: fullname: M Araki – volume: 137 start-page: 2551 year: 2018 ident: 864_CR21 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.118.035289 contributor: fullname: KV Patel – volume: 60 start-page: 473 year: 1979 ident: 864_CR72 publication-title: Circulation doi: 10.1161/01.CIR.60.3.473 contributor: fullname: DB Zilversmit – volume: 20 start-page: E706 year: 2019 ident: 864_CR141 publication-title: Int J Mol Sci doi: 10.3390/ijms20030706 contributor: fullname: K Yokote – volume: 243 start-page: 516 year: 2017 ident: 864_CR27 publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2017.05.059 contributor: fullname: CI Ponte-Negretti – volume: 370 start-page: 1687 year: 2007 ident: 864_CR146 publication-title: Lancet doi: 10.1016/S0140-6736(07)61607-9 contributor: fullname: AC Keech – volume: 121 start-page: 677 year: 2017 ident: 864_CR1 publication-title: Circ Res. doi: 10.1161/CIRCRESAHA.117.308903 contributor: fullname: P Joseph – volume: 317 start-page: 937 year: 2017 ident: 864_CR77 publication-title: JAMA doi: 10.1001/jama.2017.0972 contributor: fullname: AV Khera – volume: 369 start-page: 1090 year: 2007 ident: 864_CR92 publication-title: Lancet doi: 10.1016/S0140-6736(07)60527-3 contributor: fullname: M Yokoyama – volume: 39 start-page: 760 year: 2018 ident: 864_CR102 publication-title: Endocr Rev doi: 10.1210/er.2018-00064 contributor: fullname: N Bougarne – ident: 864_CR145 – volume: 392 start-page: 1072 year: 2018 ident: 864_CR3 publication-title: Lancet doi: 10.1016/S0140-6736(18)31992-5 contributor: fullname: NCD Countdown 2030 collaborators – volume: 103 start-page: 213 year: 2001 ident: 864_CR106 publication-title: Circulation doi: 10.1161/01.CIR.103.2.213 contributor: fullname: N Marx – volume: 8 start-page: 446 year: 2017 ident: 864_CR123 publication-title: J Diabetes Investig. doi: 10.1111/jdi.12621 contributor: fullname: K Takei – volume: 41 start-page: 538 year: 2018 ident: 864_CR136 publication-title: Diabetes Care doi: 10.2337/dc17-1589 contributor: fullname: E Araki – volume: 377 start-page: 1119 year: 2017 ident: 864_CR19 publication-title: N Engl J Med doi: 10.1056/NEJMoa1707914 contributor: fullname: PM Ridker – volume: 100 start-page: 2730 year: 2003 ident: 864_CR58 publication-title: Proc Natl Acad Sci USA. doi: 10.1073/pnas.0538015100 contributor: fullname: O Ziouzenkova – volume: 30 start-page: 1047 year: 2018 ident: 864_CR5 publication-title: Eur J Gastroenterol Hepatol doi: 10.1097/MEG.0000000000001183 contributor: fullname: OO Olubamwo – volume: 379 start-page: 2097 year: 2018 ident: 864_CR16 publication-title: N Engl J Med doi: 10.1056/NEJMoa1801174 contributor: fullname: GG Schwartz – volume: 61 start-page: 103 year: 2018 ident: 864_CR22 publication-title: Prog Cardiovasc Dis doi: 10.1016/j.pcad.2018.06.004 contributor: fullname: ME Piché – volume: 32 start-page: 1345 year: 2011 ident: 864_CR26 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehr112 contributor: fullname: MJ Chapman – volume: 11 start-page: 433 year: 1992 ident: 864_CR98 publication-title: EMBO J doi: 10.1002/j.1460-2075.1992.tb05072.x contributor: fullname: JD Tugwood – volume: 12 start-page: 173 year: 2018 ident: 864_CR134 publication-title: J Clin Lipidol. doi: 10.1016/j.jacl.2017.10.006 contributor: fullname: S Ishibashi – volume: 36 start-page: 1163 year: 2015 ident: 864_CR12 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehu505 contributor: fullname: T Jernberg – volume: 17 start-page: 4689 year: 2007 ident: 864_CR115 publication-title: Bioorg Med Chem Lett doi: 10.1016/j.bmcl.2007.05.066 contributor: fullname: Y Yamazaki – volume: 67 start-page: 1 year: 2018 ident: 864_CR151 publication-title: Diabetes. doi: 10.2337/db18-1153-p contributor: fullname: Y Sasaki – volume: 26 start-page: 608 year: 2015 ident: 864_CR120 publication-title: Trends Endocrinol Metab doi: 10.1016/j.tem.2015.09.007 contributor: fullname: A Kharitonenkov – volume: 102 start-page: 1K issue: Suppl 10 year: 2008 ident: 864_CR11 publication-title: Am J Cardiol doi: 10.1016/j.amjcard.2008.10.002 contributor: fullname: JC Fruchart – volume: 365 start-page: 2255 year: 2011 ident: 864_CR37 publication-title: N Engl J Med doi: 10.1056/NEJMoa1107579 contributor: fullname: AIM-HIGH Investigators – volume: 61 start-page: 533 year: 2015 ident: 864_CR69 publication-title: Clin Chem doi: 10.1373/clinchem.2014.234146 contributor: fullname: A Varbo – volume: 3 start-page: 225 year: 2018 ident: 864_CR93 publication-title: JAMA Cardiol. doi: 10.1001/jamacardio.2017.5205 contributor: fullname: T Aung – volume: 41 start-page: 347 year: 2015 ident: 864_CR117 publication-title: Diabetes Metab. doi: 10.1016/j.diabet.2015.02.002 contributor: fullname: A Besseiche – volume: 63 start-page: 1261 year: 2017 ident: 864_CR122 publication-title: Clin Chem doi: 10.1373/clinchem.2016.270876 contributor: fullname: KL Ong – volume: 5 start-page: 941 year: 2017 ident: 864_CR18 publication-title: Lancet Diabetes Endocrinol. doi: 10.1016/S2213-8587(17)30313-3 contributor: fullname: MS Sabatine – year: 2018 ident: 864_CR28 publication-title: J Clin Lipidol. doi: 10.1016/j.jacl.2018.11.008 contributor: fullname: W Fan – volume: 54 start-page: 280 year: 2011 ident: 864_CR9 publication-title: Diabetologia doi: 10.1007/s00125-010-1951-1 contributor: fullname: TM Davis – volume: 94 start-page: 1168 year: 2004 ident: 864_CR99 publication-title: Circ Res doi: 10.1161/01.RES.0000127122.22685.0A contributor: fullname: N Marx – volume: 64 start-page: 73 year: 2016 ident: 864_CR4 publication-title: Hepatology doi: 10.1002/hep.28431 contributor: fullname: ZM Younossi – volume: 38 start-page: 2459 year: 2017 ident: 864_CR14 publication-title: Eur Heart J. doi: 10.1093/eurheartj/ehx144 contributor: fullname: BA Ference – volume: 274 start-page: 32048 year: 1999 ident: 864_CR100 publication-title: J Biol Chem doi: 10.1074/jbc.274.45.32048 contributor: fullname: P Delerive – volume: 69 start-page: 2054 year: 2017 ident: 864_CR83 publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2017.02.030 contributor: fullname: NO Stitziel – volume: 71 start-page: 33 year: 2017 ident: 864_CR130 publication-title: Metabolism. doi: 10.1016/j.metabol.2017.02.013 contributor: fullname: T Maki – volume: 249 start-page: 36 year: 2016 ident: 864_CR132 publication-title: Atherosclerosis. doi: 10.1016/j.atherosclerosis.2016.02.029 contributor: fullname: S Ishibashi – volume: 34 start-page: 1279 year: 2013 ident: 864_CR39 publication-title: Eur Heart J doi: 10.1093/eurheartj/eht055 contributor: fullname: HPS2-THRIVE Collaborative Group – volume: 37 start-page: 2315 year: 2016 ident: 864_CR6 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehw106 contributor: fullname: MF Piepoli – volume: 138 start-page: 770 year: 2018 ident: 864_CR66 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.032318 contributor: fullname: AJ Vallejo-Vaz – volume: 23 start-page: 529 year: 2003 ident: 864_CR75 publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000054194.78240.45 contributor: fullname: LA Pennacchio – volume: 25 start-page: 521 year: 2018 ident: 864_CR133 publication-title: J Atheroscler Thromb. doi: 10.5551/jat.44412 contributor: fullname: H Arai – volume: 62 start-page: 593 year: 2016 ident: 864_CR70 publication-title: Clin Chem doi: 10.1373/clinchem.2015.253757 contributor: fullname: AM Jepsen – volume: 219 start-page: 15 year: 2011 ident: 864_CR76 publication-title: Atherosclerosis. doi: 10.1016/j.atherosclerosis.2011.07.019 contributor: fullname: SK Nilsson – volume: 37 start-page: 969 year: 2017 ident: 864_CR73 publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.116.308834 contributor: fullname: SJ Bernelot Moens – volume: 22 start-page: 754 year: 2015 ident: 864_CR119 publication-title: J Atheroscler Thromb. doi: 10.5551/jat.28720 contributor: fullname: S Raza-Iqbal – volume: 49 start-page: 755 year: 2006 ident: 864_CR57 publication-title: Diabetologia doi: 10.1007/s00125-005-0125-z contributor: fullname: M Adiels – volume: 37 start-page: 1944 year: 2016 ident: 864_CR43 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehw152 contributor: fullname: BG Nordestgaard – volume: 261 start-page: 144 year: 2017 ident: 864_CR135 publication-title: Atherosclerosis. doi: 10.1016/j.atherosclerosis.2017.03.032 contributor: fullname: H Arai – volume: 13 start-page: 731 year: 2017 ident: 864_CR62 publication-title: Nat Rev Endocrinol. doi: 10.1038/nrendo.2017.119 contributor: fullname: S Kersten – volume: 39 start-page: 385 year: 2018 ident: 864_CR23 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehx662 contributor: fullname: BK Lauridsen – year: 2018 ident: 864_CR74 publication-title: Clin Chem. doi: 10.1373/clinchem.2018.294926 contributor: fullname: SEJ Hansen – volume: 66 start-page: 1138 year: 2017 ident: 864_CR149 publication-title: Gut doi: 10.1136/gutjnl-2017-313884 contributor: fullname: LA Adams – volume: 14 start-page: 671 year: 2018 ident: 864_CR10 publication-title: Expert Opin Drug Metab Toxicol. doi: 10.1080/17425255.2018.1483337 contributor: fullname: MS Hedrington – volume: 80 start-page: 719 year: 1989 ident: 864_CR71 publication-title: Circulation doi: 10.1161/01.CIR.80.3.719 contributor: fullname: D Steinberg – volume: 591 start-page: 247 year: 2005 ident: 864_CR112 publication-title: Mutat Res doi: 10.1016/j.mrfmmm.2005.02.028 contributor: fullname: JS Lewis – volume: 376 start-page: 1713 year: 2017 ident: 864_CR15 publication-title: N Engl J Med doi: 10.1056/NEJMoa1615664 contributor: fullname: MS Sabatine – volume: 21 start-page: 366 year: 2019 ident: 864_CR54 publication-title: Diabetes Obes Metab doi: 10.1111/dom.13537 contributor: fullname: GA Nichols – volume: 36 start-page: 774 year: 2015 ident: 864_CR42 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehu500 contributor: fullname: P Libby – volume: 16 start-page: 1013 year: 2002 ident: 864_CR101 publication-title: Mol Endocrinol contributor: fullname: I Pineda Torra – year: 2018 ident: 864_CR143 publication-title: J Diabetes Investig. doi: 10.1111/jdi.12845 contributor: fullname: I Matsuba – volume: 205 start-page: 1 year: 2009 ident: 864_CR95 publication-title: Atherosclerosis. doi: 10.1016/j.atherosclerosis.2009.03.008 contributor: fullname: JC Fruchart – volume: 7 start-page: 42477 year: 2017 ident: 864_CR129 publication-title: Sci Rep. doi: 10.1038/srep42477 contributor: fullname: Y Honda – volume: 5 start-page: 145 year: 2006 ident: 864_CR7 publication-title: Expert Opin Drug Saf. doi: 10.1517/14740338.5.1.145 contributor: fullname: MH Davidson – volume: 371 start-page: 32 year: 2014 ident: 864_CR79 publication-title: N Engl J Med doi: 10.1056/NEJMoa1308027 contributor: fullname: AB Jørgensen – volume: 123 start-page: 2292 year: 2011 ident: 864_CR41 publication-title: Circulation doi: 10.1161/CIR.0b013e3182160726 contributor: fullname: M Miller – volume: 64 start-page: 219 year: 2018 ident: 864_CR131 publication-title: Clin Chem doi: 10.1373/clinchem.2017.279463 contributor: fullname: A Varbo – volume: 21 start-page: 1 issue: Suppl 1 year: 2015 ident: 864_CR88 publication-title: Endocr Pract. doi: 10.4158/EP15672.GLSUPPL contributor: fullname: Y Handelsman – volume: 101 start-page: 2777 year: 2000 ident: 864_CR44 publication-title: Circulation doi: 10.1161/01.CIR.101.24.2777 contributor: fullname: MA Austin – volume: 12 start-page: 82 year: 2013 ident: 864_CR113 publication-title: Cardiovasc Diabetol. doi: 10.1186/1475-2840-12-82 contributor: fullname: JC Fruchart – volume: 25 start-page: 142 year: 2018 ident: 864_CR124 publication-title: J Atheroscler Thromb. doi: 10.5551/jat.39693 contributor: fullname: M Sairyo – volume: 37 start-page: 2999 year: 2016 ident: 864_CR89 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehw272 contributor: fullname: AL Catapano – volume: 231 start-page: 300 year: 2013 ident: 864_CR29 publication-title: Atherosclerosis. doi: 10.1016/j.atherosclerosis.2013.09.020 contributor: fullname: Ž Reiner – volume: 384 start-page: 39 year: 1996 ident: 864_CR104 publication-title: Nature doi: 10.1038/384039a0 contributor: fullname: PR Devchand – volume: 5 start-page: 542 year: 2008 ident: 864_CR108 publication-title: Nat Clin Pract Cardiovasc Med. doi: 10.1038/ncpcardio1278 contributor: fullname: B Staels – volume: 206 start-page: 80 year: 2018 ident: 864_CR144 publication-title: Am Heart J doi: 10.1016/j.ahj.2018.09.011 contributor: fullname: AD Pradhan – volume: 51 start-page: 724 year: 2008 ident: 864_CR47 publication-title: J Am Coll Cardiol. doi: 10.1016/j.jacc.2007.10.038 contributor: fullname: M Miller – volume: 15 start-page: 534 year: 1995 ident: 864_CR64 publication-title: Arterioscler Thromb Vasc Biol. doi: 10.1161/01.ATV.15.4.534 contributor: fullname: BG Nordestgaard – volume: 380 start-page: 11 year: 2018 ident: 864_CR94 publication-title: N Engl J Med doi: 10.1056/NEJMoa1812792 contributor: fullname: DL Bhatt – volume: 23 start-page: 351 year: 2012 ident: 864_CR107 publication-title: Trends Endocrinol Metab doi: 10.1016/j.tem.2012.05.001 contributor: fullname: W Wahli – volume: 115 start-page: 518 year: 2007 ident: 864_CR60 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.104.475673 contributor: fullname: JD Brown – year: 2018 ident: 864_CR87 publication-title: J Am Coll Cardiol. doi: 10.1016/j.jacc.2018.11.003 contributor: fullname: SM Grundy – volume: 367 start-page: 2089 year: 2012 ident: 864_CR38 publication-title: N Engl J Med doi: 10.1056/NEJMoa1206797 contributor: fullname: GG Schwartz – volume: 371 start-page: 22 year: 2014 ident: 864_CR80 publication-title: N Engl J Med. doi: 10.1056/NEJMoa1307095 contributor: fullname: J Crosby – volume: 363 start-page: 233 year: 2010 ident: 864_CR147 publication-title: N Engl J Med. doi: 10.1056/NEJMoa1001288 contributor: fullname: EY Chew – volume: 298 start-page: 299 year: 2007 ident: 864_CR45 publication-title: JAMA doi: 10.1001/jama.298.3.299 contributor: fullname: BG Nordestgaard – volume: 35 start-page: 1008 year: 2012 ident: 864_CR8 publication-title: Diabetes Care doi: 10.2337/dc11-1811 contributor: fullname: JC Mychaleckyj – volume: 298 start-page: 309 year: 2007 ident: 864_CR46 publication-title: JAMA doi: 10.1001/jama.298.3.309 contributor: fullname: S Bansal – volume: 28 start-page: 27 year: 2017 ident: 864_CR86 publication-title: Curr Opin Lipidol doi: 10.1097/MOL.0000000000000372 contributor: fullname: L Juntti-Berggren – volume: 6 start-page: 325 year: 2012 ident: 864_CR30 publication-title: J Clin Lipidol. doi: 10.1016/j.jacl.2012.05.002 contributor: fullname: PP Tóth – volume: 141 start-page: 358 year: 2014 ident: 864_CR67 publication-title: Pharmacol Ther doi: 10.1016/j.pharmthera.2013.11.008 contributor: fullname: A Varbo – volume: 2 start-page: 370 year: 2017 ident: 864_CR91 publication-title: JAMA Cardiol. doi: 10.1001/jamacardio.2016.4828 contributor: fullname: MB Elam – volume: 391 start-page: 219 year: 2018 ident: 864_CR20 publication-title: Lancet doi: 10.1016/S0140-6736(17)32409-1 contributor: fullname: SS Anand – volume: 52 start-page: 339 year: 2018 ident: 864_CR148 publication-title: J Clin Gastroenterol doi: 10.1097/MCG.0000000000000925 contributor: fullname: I Doycheva – volume: 52 start-page: 187 year: 2016 ident: 864_CR61 publication-title: Endocrine doi: 10.1007/s12020-015-0838-9 contributor: fullname: A Tikka – volume: 7 start-page: e008740 year: 2018 ident: 864_CR55 publication-title: J Am Heart Assoc. doi: 10.1161/JAHA.118.008740 contributor: fullname: PP Toth – ident: 864_CR2 – volume: 104 start-page: 459 year: 2009 ident: 864_CR48 publication-title: Am J Cardiol doi: 10.1016/j.amjcard.2009.04.008 contributor: fullname: O Faergeman – volume: 374 start-page: 1123 year: 2016 ident: 864_CR81 publication-title: N Engl J Med doi: 10.1056/NEJMoa1510926 contributor: fullname: FE Dewey – volume: 17 start-page: 160 year: 2017 ident: 864_CR31 publication-title: BMC Cardiovasc Disord. doi: 10.1186/s12872-017-0591-5 contributor: fullname: JP Halcox – volume: 129 start-page: 999 year: 2014 ident: 864_CR13 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.113.002529 contributor: fullname: FM Sacks – volume: 34 start-page: 615 year: 2013 ident: 864_CR85 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehs271 contributor: fullname: C Zheng – volume: 65 start-page: 2267 year: 2015 ident: 864_CR50 publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2015.03.544 contributor: fullname: GG Schwartz – volume: 380 start-page: 572 year: 2012 ident: 864_CR35 publication-title: Lancet doi: 10.1016/S0140-6736(12)60312-2 contributor: fullname: BF Voight – volume: 31 start-page: 811 year: 2008 ident: 864_CR33 publication-title: J Am Coll Cardiol contributor: fullname: JD Brunzell – volume: 9 start-page: 1605 year: 2018 ident: 864_CR110 publication-title: Front Immunol doi: 10.3389/fimmu.2018.01605 contributor: fullname: A Angajala – volume: 374 start-page: 1134 year: 2016 ident: 864_CR82 publication-title: N Engl J Med. doi: 10.1056/NEJMoa1507652 contributor: fullname: NO Stitziel – volume: 102 start-page: 1886 year: 2000 ident: 864_CR84 publication-title: Circulation doi: 10.1161/01.CIR.102.16.1886 contributor: fullname: FM Sacks – volume: 384 start-page: 626 year: 2014 ident: 864_CR56 publication-title: Lancet doi: 10.1016/S0140-6736(14)61177-6 contributor: fullname: BG Nordestgaard – volume: 36 start-page: 1048 year: 2015 ident: 864_CR137 publication-title: Eur Heart J. contributor: fullname: JJP Kastelein – volume: 297 start-page: 1362 year: 2007 ident: 864_CR114 publication-title: JAMA doi: 10.1001/jama.297.12.1362 contributor: fullname: SE Nissen – volume: 23 start-page: 441 year: 2016 ident: 864_CR121 publication-title: Cell Metab doi: 10.1016/j.cmet.2016.01.006 contributor: fullname: C Schlein – volume: 56 start-page: e98 year: 2014 ident: 864_CR32 publication-title: Cor et Vasa. doi: 10.1016/j.crvasa.2014.02.002 contributor: fullname: B Nussbaumerová – volume: 302 start-page: 1993 year: 2009 ident: 864_CR34 publication-title: JAMA doi: 10.1001/jama.2009.1619 contributor: fullname: The Emerging Risk Factors Collaboration – volume: 12 start-page: 1267 year: 2018 ident: 864_CR139 publication-title: J Clin Lipidol. doi: 10.1016/j.jacl.2018.06.010 contributor: fullname: S Yamashita – volume: 60 start-page: 123 year: 2000 ident: 864_CR111 publication-title: Vitam Horm doi: 10.1016/S0083-6729(00)60018-3 contributor: fullname: V Krishnan – volume: 61 start-page: 427 year: 2013 ident: 864_CR68 publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2012.08.1026 contributor: fullname: A Varbo – ident: 864_CR150 – volume: 35 start-page: 2218 year: 2015 ident: 864_CR63 publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.115.305614 contributor: fullname: J Borén – volume: 96 start-page: 1737 year: 1997 ident: 864_CR78 publication-title: Circulation doi: 10.1161/01.CIR.96.6.1737 contributor: fullname: BG Nordestgaard – volume: 16 start-page: 124 year: 2017 ident: 864_CR118 publication-title: Cardiovasc Diabetol. doi: 10.1186/s12933-017-0602-y contributor: fullname: JC Fruchart |
| SSID | ssj0017861 |
| Score | 2.553303 |
| SecondaryResourceType | review_article |
| Snippet | In the era of precision medicine, treatments that target specific modifiable characteristics of high-risk patients have the potential to lower further the... |
| SourceID | pubmedcentral proquest crossref pubmed |
| SourceType | Open Access Repository Aggregation Database Index Database |
| StartPage | 71 |
| SubjectTerms | Animals Benzoxazoles - adverse effects Benzoxazoles - therapeutic use Biomarkers - blood Butyrates - adverse effects Butyrates - therapeutic use Cardiovascular Diseases - blood Cardiovascular Diseases - diagnosis Cardiovascular Diseases - prevention & control Consensus Dyslipidemias - blood Dyslipidemias - diagnosis Dyslipidemias - drug therapy Humans Hypolipidemic Agents - adverse effects Hypolipidemic Agents - therapeutic use Lipids - blood Molecular Targeted Therapy Patient Safety PPAR alpha - agonists PPAR alpha - metabolism Review Risk Assessment Risk Factors Signal Transduction Treatment Outcome |
| Title | The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/31164165 https://www.proquest.com/docview/2315970017 https://pubmed.ncbi.nlm.nih.gov/PMC6549355 |
| Volume | 18 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LbtNAFL0iXSA2VcujTQvRILEApGk8HscPdlVoVYSCIgpSd9Z4HhCptqM6qfoR_Ex_hG_i3rEdpbBjZ3tsy_K5mnuO7gvgjcycDlxhOYW0eGR0yAslUj4JQm1j8lm-E9PFZfLlKv14Rm1yJn0tjE_a18XipLouT6rFT59buSz1uM8TG89n0xhFDfrJ8QAGyA17id6FDpI0Fl34UqTxuCGHRilDGUf2HnGauicFigRB_mTbF_1DMP_Ok9xyPOd7sNsxRnbaftk-PLLVU3g862Liz-AXIs0aP84Gdy5Gjb_vFk1d4iFN5HHWB9I5FTDcIrE0DPc4u8RLzNfZsrI2NMILz99ezuenX2e_798x6ghuFj_KD0y3dY1r_ATXJ3IxVRm2VbnFlvWKso7U9XP4fn72bXrBuxkLXMsgWvECBZUmEREjfy20wZ8XKueyiZEysJGWiJ6VLg4NUh1hRVhYJ53Cx1BpSVx6ATtVXdlDYJlKaRplqITKIl1IJRKlUX1PCnSTWkZDeN__7XzZttLIvQRJ47xFKUeUckIpT4bwuscjR4OnKIaqbL1uciSkKIII6CEctPhsXtcDO4TkAXKbG6iZ9sMVtDHfVLuzqaP_fvIYnoTeymIeRC9hZ3Wztq9g0Jj1CKn6p88jL_dH3lj_AJO78Rk |
| link.rule.ids | 230,315,729,782,786,866,887,27933,27934,53800,53802 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3bbtQwEB3RIkFfuEOXq5F4ACR34zibC29VabWIbrWiReLNcnyBlZpkRXYRH8HP8CN8EzNOUm3hrW9JHEdWztgzR3MDeCULbyJfOk4uLZ5YE_NSi5xPoti4lHRWqMQ0Pc1OvuTvD6lMzmTIhQlB-6Zc7NXn1V69-BZiK5eVGQ9xYuP57CBFUoN6crwF13G_RtFA0nvnQZanondgijwdt6TSKGio4Gi_J5z67kmBNEGQRtnURv-ZmP9GSm6onqPbV1z0HbjV25psvxu-C9dcfQ9uzHpv-n34hTLC2tAIB888RiXDfy7apsJL6uXjXXDBc0p9-IEmqWV4OrolPmIhQ5dVjaXmX3j_-nQ-3_80-_P7DaNa4nbxtXrHTJcRucYl-CEEjOnaso2cL7ZsVhSvpM8fwOejw7ODKe-7M3Ajo2TFS6RihuhHipZvaSz-9Fh7X0yslJFLjETcnfRpbNFIEk7EpfPSa5yGHE3i0EPYrpva7QIrdE59LGMtdJGYUmqRaYO8fVKigjUyGcHbASW17IpwqEBe8lR16CpEVxG6KhvBywFHhVuF_B-6ds26VWjKIn0iARnBow7Xi88NAjGC7BLiFy9QGe7LIwh0KMfdA_v4yjNfwM3p2exYHX84-fgEduIgqSmPkqewvfq-ds9gq7Xr50HI_wKn2wTH |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3JbtRAEC2RIEVc2AnD2kgcAKljt9vjhVuUZBQEE40ISNysdi8wUrwIzyA-gp_hR_gmqtr2aAI3uNnuttXyq-6qp9oAnsvc6dCVlpNLi8dGR7xUIuPTMNI2IZ3lKzGdnqdnn7LjEyqTs2n15YP2dbk8qC-qg3r5xcdWtpUOxjixYDE_SpDUoJ4MWuOCHbiKezaMRqI-OBDSLBGDE1NkSdCRWqPAoZyjDR9z6r0nBVIFQVplWyP9ZWb-GS25pX5mN_5j4Tfh-mBzssN-yi24YuvbsDcfvOp34AfKCut8Qxw8-xiVDv--7JoKL6mnj7PeFc8pBeIbmqaG4SlpW3zEfKYuqxpDTcDw_sX5YnH4fv7r50tGNcXN8nP1muk-M3KNS3BjKBhTtWFbuV-sbVYUt6Qu7sLH2cmHo1M-dGngWobxipdIyTTRkAQt4FIb_PGRci6fGilDG2uJ-FvpksigsSSsiErrpFP4GnI1iUP3YLduansfWK4y6mcZKaHyWJdSiVRp5O_TEhWtlvEEXo1IFW1fjKPwJCZLih7hAhEuCOEincCzEcsCtwz5QVRtm3VXoEmLNIqEZAL7Pbabz41CMYH0EuqbCVSO-_IIgu3Lcg_gPvjnN5_C3uJ4Vrx7c_b2IVyLvLAmPIwfwe7q69o-hp3OrJ94Of8NwdkHRw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+selective+peroxisome+proliferator-activated+receptor+alpha+modulator+%28SPPARM%CE%B1%29+paradigm%3A+conceptual+framework+and+therapeutic+potential+%3A+A+consensus+statement+from+the+International+Atherosclerosis+Society+%28IAS%29+and+the+Residual+Risk+Reduction+Initiative+%28R3i%29+Foundation&rft.jtitle=Cardiovascular+diabetology&rft.au=Fruchart%2C+Jean-Charles&rft.au=Santos%2C+Raul+D&rft.au=Aguilar-Salinas%2C+Carlos&rft.au=Aikawa%2C+Masanori&rft.date=2019-06-04&rft.issn=1475-2840&rft.eissn=1475-2840&rft.volume=18&rft.issue=1&rft.spage=71&rft_id=info:doi/10.1186%2Fs12933-019-0864-7&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1475-2840&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1475-2840&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1475-2840&client=summon |