A complementary method to obtain N-acyl enamides using the Heck reaction: extending the substrate scope for asymmetric hydrogenation

A series of N-acyl enamides were prepared using the Heck reaction. Asymmetric hydrogenation provided protected amines in up to 99% ee. A method to prepare N-acyl enamides is reported that is complementary to the existing protocols. Heck reaction of a variety of aryl trifluoromethanesulfonates with c...

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Bibliographic Details

Published in:	Tetrahedron letters Vol. 45; no. 50; pp. 9277 - 9280
Main Authors:	Harrison, Paul, Meek, Graham
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 06-12-2004
Subjects:	Asymmetric hydrogenation Heck reaction N-Acyl enamides Heck reaction Asymmetric hydrogenation N-Acyl enamides
Online Access:	Get full text
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