Non thiazolidinedione antihyperglycaemic agents. 1: α-Heteroatom substituted β-phenylpropanoic acids

• Published in: Bioorganic & medicinal chemistry letters Vol. 6; no. 17; pp. 2121 - 2126
• Main Authors: Buckle, D.R., Cantello, B.C.C., Cawthorne, M.A., Coyle, P.J., Dean, D.K., Faller, A., Haigh, D., Hindley, R.M., Jefcott, L.J., Lister, C.A., Pinto, I.L., Rami, H.K., Smith, D.G., Smith, S.A.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 03-09-1996
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/0960-894X(96)00383-6

The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitising antidiabetic agents can be replaced by a range of α-heteroatom functionalised β-phenylpropanoic acids. α-Oxy-carboxylic acids show potent antidiabetic activity and one compound, the α-ethoxyacid
15 (SB 213068), is one of the most potent antihyperglycaemic agents yet reported.
The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitising antidiabetic agents can be replaced by a range of α-heteroatom functionalised β-phenylpropanoic acids. α-Oxy-carboxylic acids show potent antidiabetic activity and one compound, the α-ethoxyacid
15 (SB 213068), is one of the most potent antihyperglycaemic agents yet reported.