Human gp130 transducer chain gene (IL6ST) is localized to chromosome band 5q11 and possesses a pseudogene on chromosome band 17p11

Human gp130 (IL6ST) is one of the most widely used chains of the cytokine receptor family. Indeed, it is involved in signal transduction of interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. In a previous report, IL6ST was assigned to chromosome...

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Bibliographic Details
Published in:	Cytogenetics and cell genetics Vol. 70; no. 1-2; p. 64
Main Authors:	Rodriguez, C, Grosgeorge, J, Nguyen, V C, Gaudray, P, Theillet, C
Format:	Journal Article
Language:	English
Published:	Switzerland 1995
Subjects:	Antigens, CD Base Sequence Chromosomes, Human, Pair 17 Chromosomes, Human, Pair 5 Cytokine Receptor gp130 Humans In Situ Hybridization, Fluorescence Membrane Glycoproteins - genetics Molecular Sequence Data Polymerase Chain Reaction Polymorphism, Single-Stranded Conformational Pseudogenes - genetics
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Summary:	Human gp130 (IL6ST) is one of the most widely used chains of the cytokine receptor family. Indeed, it is involved in signal transduction of interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. In a previous report, IL6ST was assigned to chromosomes 5 and 17. Here we specify the chromosomal sublocalization of IL6ST and show that the sequence detected on 17p11 corresponds, in fact, to a nontranscribed pseudogene, whereas the active gene is located at chromosome band 5q11.
ISSN:	0301-0171
DOI:	10.1159/000133993