Mitochondrial dysfunction and diabetic retinopathy

Mitochondrial dysfunction and diabetic retinopathy

Mitochondrial dysfunction may predispose to the development of diabetes mellitus with the accompanying risk for developing diabetic retinopathy or may contribute directly to the diabetic metabolic dysregulation and thereby increase the risk of diabetic late complications including retinopathy. Diabe...

Full description

Saved in:
Bibliographic Details
Published in:Mitochondrion Vol. 36; pp. 4 - 6
Main Author: Bek, Toke
Format: Journal Article
Language:English
Published: Netherlands 01-09-2017
Subjects:
Diabetic Retinopathy - physiopathology
Epigenesis, Genetic
Humans
Mitochondria - genetics
Mitochondria - pathology
Mitochondria - physiology
Reactive Oxygen Species - metabolism
Syndromes
Diabetic retinopathy
Mitochondrial dysfunction
Metabolism
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mitochondrial dysfunction may predispose to the development of diabetes mellitus with the accompanying risk for developing diabetic retinopathy or may contribute directly to the diabetic metabolic dysregulation and thereby increase the risk of diabetic late complications including retinopathy. Diabetes mellitus in mitochondrial disease can lead to the development of vision threatening retinopathy, but visual acuity is often reduced secondary to neurological deficits resulting from the mitochondrial dysfunction. The relation between mitochondrial disease and diabetic retinopathy can be influenced by epigenetics where factors in the environment modify the expression of regulatory proteins coding for the elimination of reactive oxygen species.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1567-7249
1872-8278
DOI:10.1016/j.mito.2016.07.011