Distinct functional domains in nesprin-1α and nesprin-2β bind directly to emerin and both interactions are disrupted in X-linked Emery–Dreifuss muscular dystrophy

Emerin and specific isoforms of nesprin-1 and -2 are nuclear membrane proteins which are binding partners in multi-protein complexes spanning the nuclear envelope. We report here the characterisation of the residues both in emerin and in nesprin-1α and -2β which are involved in their interaction and...

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Bibliographic Details

Published in:	Experimental cell research Vol. 313; no. 13; pp. 2845 - 2857
Main Authors:	Wheeler, Matthew A., Davies, John D., Zhang, Qiuping, Emerson, Lindsay J., Hunt, James, Shanahan, Catherine M., Ellis, Juliet A.
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 01-08-2007
Subjects:	Emerin Emery–Dreifuss muscular dystrophy Nesprin-1 and -2 Emerin Emery–Dreifuss muscular dystrophy Nesprin-1 and -2
Online Access:	Get full text
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